Painkiller and anti-inflammatory (NSAID + Analgesic combination)
Brand of Ibuprofen; Paracetamol
Last reviewed April 2026
NAFDAC registration currently inactive
This product's NAFDAC registration is not currently active. It may still be available in pharmacies, but you should verify its status with your pharmacist before use.
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This is a combination painkiller that contains two medicines — Ibuprofen and Paracetamol — that work together in different ways to reduce pain, fever, and swelling, giving you stronger relief than either one alone.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
For adults, the usual dose is 1 tablet (typically containing Ibuprofen 400mg + Paracetamol 325mg) taken 3 times a day after food. Always take it with food or immediately after eating to protect your stomach. Do not take more than 3 tablets in 24 hours. Do not use it continuously for more than 5 days for pain or 3 days for fever without seeing a doctor. You can find this combination sold as Brustan Plus, Ibulock Plus, or Lotemp Plus in pharmacies.
Since this drug is usually taken only when you have pain or fever, there is no strict schedule. If you are taking it regularly as advised by your doctor and you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one — never take a double dose to make up for it.
Buy only from licensed pharmacies — avoid roadside vendors or open market sellers, as fake or expired drugs are common and can be very dangerous. Do not combine this with other Paracetamol-containing drugs like Panadol Extra, cold and flu medicines, or other painkillers — overdose of Paracetamol can silently damage your liver. If your pain or fever does not improve after 3 to 5 days, see a doctor instead of continuing to self-medicate.
Avoid taking this with other painkillers like aspirin or diclofenac (Voltaren/Cataflam) as it increases the risk of stomach bleeding. Do not take extra Paracetamol (like Panadol or Emzor Paracetamol) alongside this drug, because this combination already contains Paracetamol — taking more can seriously damage your liver. Avoid drinking alcohol while using this medicine, as it increases the risk of stomach problems and liver damage.
Check your specific combination
Is it safe to take Ibuprofen; with your other drugs?
Do not use this drug during pregnancy, especially in the last 3 months, and consult your doctor before using it while breastfeeding.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so do not leave it in your car or near a window. Keep it in its original pack and away from moisture. Always keep it out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for P-Espen Tablets
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NAFDAC Number
B4-1244
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