Antibiotic (Cephalosporin) with Local Anaesthetic
Last reviewed July 2026
Who is this for?
Ceftriaxone with Lidocaine is a strong antibiotic injection where ceftriaxone kills bacteria causing infections and lidocaine is a pain reliever mixed in to reduce the pain of the injection at the injection site.
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing peptidoglycan cross-linking, while lidocaine blocks voltage-gated sodium channels to provide local anesthesia at the injection site.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Since this injection is usually given by a healthcare worker, if you miss your scheduled injection, go to the hospital or clinic as soon as possible to get it. Do not try to double the dose to make up for the missed one.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Always get this injection from a qualified nurse or doctor at a hospital or registered clinic, never from roadside medicine sellers or untrained people. Complete the full course of injections your doctor prescribed even if you feel better after 2 or 3 days, otherwise the infection can come back stronger and become resistant. The lidocaine version is only for injection into the muscle: it must never be injected into a vein (IV).
Do not use with calcium-containing IV drips (like Ringer's lactate) as it can form dangerous particles in the blood. Blood thinners like warfarin: ceftriaxone can increase the risk of bleeding, so tell your doctor if you take warfarin. Avoid taking with other antibiotics like chloramphenicol unless your doctor says so, as they may work against each other.
Check your specific combination
Is it safe to take Ceftriaxone with your other drugs?
Ceftriaxone should only be used during pregnancy or breastfeeding if your doctor decides the benefit is greater than the risk, so always consult your doctor first.
Store the unopened powder in a cool, dry place below 25°C, away from direct sunlight and heat, which is important in Nigeria's hot climate. Once mixed with the lidocaine solution, use it immediately or within a few hours. Keep out of reach of children at all times.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.