Antibiotic (Cephalosporin + Beta-lactamase inhibitor)
Brand of Ceftriaxone and Sulbactam
Last reviewed June 2026
Who is this for?
Ceftriaxone and Sulbactam is a combination antibiotic injection. Ceftriaxone kills bacteria by stopping them from building their protective walls, while Sulbactam helps by blocking a trick some bacteria use to resist the antibiotic — making the combination stronger against tough infections.
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing peptidoglycan cross-linking; sulbactam irreversibly inhibits beta-lactamases, protecting ceftriaxone from enzymatic degradation and extending activity against resistant gram-negative and anaerobic organisms.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
This drug is given as an injection by a doctor, nurse, or trained health worker — it is not something you take at home by yourself. The usual adult dose is 1.5g (1g ceftriaxone + 0.5g sulbactam) to 3g given once or twice daily, depending on how serious the infection is. Your doctor will decide the exact dose and how long you need it.
Since this injection is usually given in a hospital or clinic, a missed dose is unlikely. However, if you miss a scheduled dose, contact your doctor or nurse immediately so they can give it as soon as possible. Do not double up doses.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Always complete the full course of injections your doctor prescribed — stopping early because you feel better can cause the infection to come back stronger and harder to treat. Only receive this injection at a hospital, clinic, or pharmacy with a trained professional — never buy and inject yourself at home. Make sure the injection is from a reputable pharmacy, not roadside sellers, to avoid fake or expired products.
Avoid using with blood thinners like warfarin, as it can increase bleeding risk — inform your doctor if you take any. Do not mix with calcium-containing IV fluids (like Ringer's lactate), as dangerous particles can form. Avoid alcohol during treatment as it can worsen side effects and slow your recovery.
Check your specific combination
Is it safe to take Ceftriaxone with your other drugs?
Consult your doctor before using this drug if you are pregnant or breastfeeding — it should only be used if the doctor decides the benefit outweighs the risk to the baby.
Store the unopened powder in a cool, dry place below 30°C — away from direct sunlight and humidity, which is especially important in hot Nigerian weather. Once mixed with water for injection, use it promptly or store in a fridge and use within the time your pharmacist advises. Always keep out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Oframax S Injection 1500 mg
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NAFDAC Number
C4-0168
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