Syphilis

5 drugs · 5 Prescription

STIs & Sexual Health

Penicillin and alternatives for syphilis treatment

Progresses in stages: an early painless sore is easy to miss, but the infection keeps spreading if untreated

Penicillin injection is the standard treatment; tell your doctor if you're allergic so an alternative can be used

When to see a doctor

Seek care if you notice any of the following

  • If you have a severe headache, confusion, or difficulty speaking, go to your nearest clinic or hospital immediately.
  • If you notice a rash that spreads quickly, especially to your palms, soles, or face, go to your nearest clinic or hospital soon.
  • If you have a fever over 38°C (100.4°F) that lasts for more than 3 days, go to your nearest clinic or hospital soon.
  • If you experience severe pain in your joints, muscles, or bones, go to your nearest clinic or hospital soon.
  • If you have a sore on your genitals, anus, or mouth that doesn't heal after 2 weeks of treatment with penicillin, go to your nearest clinic or hospital soon.

For guidance only: always consult a qualified healthcare provider.