Antiviral (Direct-Acting Antiviral for Hepatitis C)
Last reviewed June 2026
Who is this for?
Sofosbuvir is an antiviral medicine that works by blocking the hepatitis C virus from multiplying in your body, helping your liver to heal over time.
Inhibits hepatitis C virus (HCV) RNA-dependent RNA polymerase (NS5B), preventing viral replication and reducing viral load. Functions as a nucleotide analogue that integrates into the growing viral RNA chain, causing chain termination and blocking the production of infectious viral particles.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Take one 400mg tablet once a day, with or without food. Sofosbuvir is never used alone — it is always taken together with other antiviral medicines as prescribed by your doctor. A typical treatment course lasts 12 to 24 weeks depending on your type of hepatitis C.
If you miss a dose and remember within 18 hours, take it as soon as you remember. If it is close to your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.
Always buy from a licensed pharmacy — fake hepatitis C medicines are common in Nigeria, and brands like MyHep should be verified for authenticity. Complete the full treatment course even if you feel better, as stopping early can allow the virus to come back stronger. Do not share this medicine with anyone else, even if they also have hepatitis C, because treatment depends on the specific type of virus and liver condition.
Do not take sofosbuvir with amiodarone (a heart medicine) as it can cause dangerously slow heartbeat. Rifampicin, commonly used to treat tuberculosis (TB) in Nigeria, can reduce the effectiveness of sofosbuvir — tell your doctor if you are on TB treatment. St. John's Wort (a herbal supplement) should also be avoided as it reduces how well the drug works.
Check your specific combination
Is it safe to take Sofosbuvir with your other drugs?
Sofosbuvir is generally not recommended during pregnancy or breastfeeding unless your doctor decides the benefit outweighs the risk — always consult your doctor before using it if you are pregnant, planning to become pregnant, or breastfeeding.
Store at room temperature below 30°C in a cool, dry place away from direct sunlight and humidity. Keep the tablets in their original container and always keep out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.