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This product's NAFDAC registration is not currently active. It may still be available in pharmacies, but you should verify its status with your pharmacist before use.
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Proguanil is an antimalarial drug that works by stopping the malaria parasite from multiplying inside your body, helping to prevent malaria infection before it takes hold.
Inhibits dihydrofolate reductase in Plasmodium parasites, disrupting the synthesis of dihydrofolate and subsequently tetrahydrofolate, which are essential cofactors for nucleotide synthesis and parasite DNA replication. The active metabolite cycloguanil also inhibits bacterial dihydrofolate reductase, enhancing antimalarial activity particularly against P. falciparum and P. vivax.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
For malaria prevention, take 2 tablets (200 mg) once daily with food or a milky drink. Start taking it 1-2 days before entering a malaria area, continue throughout your stay, and keep taking it for 4 weeks after you leave the area. Swallow the tablet whole with water — taking it after food helps reduce stomach upset. Proguanil is often used together with chloroquine for better protection.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for the one you missed.
Proguanil is mainly for malaria prevention, not treatment — if you already have malaria symptoms like fever, body pain, and chills, see a doctor for proper treatment. Buy only from reputable pharmacies — brands like Paludrine, Reludrine, Mayanil, or Tegunil are known in Nigeria. Do not stop taking it early even if you feel fine — complete the full course including the 4 weeks after leaving the malaria area.
Proguanil may reduce the effectiveness of the typhoid vaccine (oral type), so let your doctor know if you are being vaccinated. Antacids and magnesium-containing medicines can reduce how well proguanil works — space them at least 2 hours apart. Warfarin (blood-thinning medicine) effects may be increased when taken with proguanil, so your doctor may need to adjust your warfarin dose.
Check your specific combination
Is it safe to take Proguanil with your other drugs?
Proguanil is generally considered safe during pregnancy and breastfeeding at recommended doses, but always consult your doctor before using it, and take folic acid supplements alongside it.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tablets in their original packaging and far out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Tegunil 100 mg Tablets
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NAFDAC Number
A4-2019
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