Antimalarial
Last reviewed July 2026
Who is this for?
Artemisinin-Piperaquine is an antimalarial combination drug that works by killing the malaria parasite in your blood in two ways: artemisinin acts fast to clear the parasites quickly, while piperaquine stays longer in your body to make sure the parasites don't come back.
Inhibits Plasmodium falciparum by dual mechanisms: artemisinin generates reactive oxygen species through cleavage of its endoperoxide bridge, causing parasite damage, while piperaquine intercalates into parasitic DNA and inhibits heme polymerization, preventing detoxification of toxic heme byproducts.
Malaria, including uncomplicated malaria caused by the most common type of malaria parasite in Nigeria
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for the one you missed.
Always complete the full 3-day course, as stopping early can make the malaria come back and become harder to treat. Buy only from trusted pharmacies and not roadside sellers, as fake antimalarials are common in Nigeria. Do not share your malaria medication with anyone, even if they have similar symptoms; let them get tested and get their own prescription.
Avoid taking this drug with other medicines that can affect your heart rhythm, such as some antibiotics like erythromycin or antifungals like ketoconazole. Avoid alcohol while on this medication as it can increase dizziness and stomach upset. If you are taking any other malaria drugs or medications for heart problems, tell your doctor or pharmacist before starting this drug.
Check your specific combination
Is it safe to take Artemisinin; with your other drugs?
This drug is generally not recommended during the first 3 months of pregnancy; if you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before taking it.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so don't leave it in your car or near a window. Keep the drug in its original packaging and far away from children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.