Antimalarial
Last reviewed July 2026
Who is this for?
Artesunate and Pyronaridine (sold as Pyramax in Nigeria) is a combination antimalarial drug that works by killing the malaria parasite in your blood from two different angles, making it very effective at clearing the infection.
Inhibits Plasmodium parasites through dual mechanisms: artesunate generates reactive oxygen species via interaction with parasite heme, while pyronaridine intercalates into parasite DNA and inhibits protein synthesis. Together, these agents rapidly eliminate parasitaemia, including multidrug-resistant strains.
Malaria (including stubborn malaria that doesn't respond easily to other drugs)
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember on the same day. If it's already close to the next day's dose, skip the missed one and continue with your normal schedule. Do not take a double dose to make up for it. Missing doses can make the malaria come back, so try your best to complete the full 3 days.
Always buy Pyramax from a registered pharmacy, avoiding roadside sellers or market vendors as fake antimalarials are common in Nigeria and can be dangerous. Complete the full 3-day course even if you feel better after day one, otherwise the malaria can come back stronger. If your symptoms don't improve after finishing the course, go back to the hospital for a proper test.
Avoid taking this drug with other antimalarials like chloroquine or amodiaquine as it can increase the risk of heart or liver problems. Be cautious if you are taking any drugs that affect the liver. Avoid alcohol while on this medication as it can put extra stress on your liver.
Check your specific combination
Is it safe to take Artesunate; with your other drugs?
This drug is not recommended during pregnancy, especially in the first 3 months, and should be avoided while breastfeeding unless your doctor specifically tells you otherwise.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid storing near windows or in your car. Keep the drug in its original packaging and away from moisture. Always keep out of reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.