How do you take Arterolane; Piperaquine?

For adults, take one tablet once a day for 3 days. Take it with water, preferably with food to reduce stomach upset. Make sure you complete all 3 days even if you start feeling better after the first day. In Nigeria, this is sold as Synriam Tablets.

What are the side effects of Arterolane; Piperaquine?

Headache, feeling like vomiting or actually vomiting, stomach pain, loss of appetite, feeling tired or weak

Who should not take Arterolane; Piperaquine?

People who are allergic to arterolane, piperaquine, or any ingredient in the tablet. People with heart problems especially irregular heartbeat (long QT syndrome). People with severe liver or kidney disease. Pregnant or breastfeeding women should avoid it unless directed by a doctor.

Prescription

Antimalarial

Arterolane; Piperaquine

Last reviewed July 2026

Who is this for?

For adults (18+). Standard adult dosing applies: see the How to Take tab for full instructions.

What is this drug?

Arterolane and Piperaquine is a combination antimalarial drug that works by killing the malaria parasite in your blood. Arterolane acts fast to clear the parasites quickly while Piperaquine keeps working longer to make sure they don't come back.

How it works

Inhibits plasmodial cytochrome bc1 complex (artemisinins) and ferriprotoporphyrin IX polymerase (piperaquine), disrupting parasite mitochondrial function and heme detoxification, thereby killing intraerythrocytic Plasmodium parasites at multiple lifecycle stages.

What is it used for?

Malaria (especially the type caused by the most common malaria parasite in Nigeria)

Browse by condition

Malaria

Prescription Required

You need a doctor's prescription to buy this drug.

Quick Interaction Check

Is Arterolane; safe to take with another drug?

Check with multiple drugs →

Explore this drug

What to watch out for

Always complete the full 3-day course even if you feel better, as stopping early can cause the malaria to come back stronger. Buy only from trusted pharmacies and avoid roadside sellers as fake antimalarials are common in Nigeria. Do not share your malaria medication with someone else even if they have similar symptoms. Let them see a doctor instead.

Common Side Effects

Headache
feeling like vomiting or actually vomiting
stomach pain
loss of appetite
feeling tired or weak

Serious Side Effects

Irregular or fast heartbeat (palpitations): see a doctor immediately. Severe skin rash
swelling of the face or difficulty breathing
which could be a sign of a serious allergic reaction: go to the hospital right away.

Drug Interactions

Avoid taking with other antimalarial drugs like chloroquine or lumefantrine as this can affect your heart rhythm. Be careful with drugs that affect the heart such as some antibiotics (like erythromycin) and certain antifungals (like ketoconazole). Avoid alcohol while taking this medication as it can increase side effects and put extra stress on your liver.

Check your specific combination

Is it safe to take Arterolane; with your other drugs?

Check →

Pregnancy & Breastfeeding Warning

This drug is not recommended during pregnancy or breastfeeding unless your doctor specifically prescribes it, so always consult your doctor first.

Who Should NOT Take This

People who are allergic to arterolane
piperaquine
or any ingredient in the tablet. People with heart problems especially irregular heartbeat (long QT syndrome). People with severe liver or kidney disease. Pregnant or breastfeeding women should avoid it unless directed by a doctor.

How to Store

Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the tablets in their original pack and store away from children.

For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.