Mayanil 100 mg Tablet

Who is this for?

Proguanil is an antimalarial drug that works by stopping the malaria parasite from multiplying inside your body, helping to prevent malaria infection before it takes hold.

Inhibits dihydrofolate reductase in Plasmodium parasites, disrupting the synthesis of dihydrofolate and subsequently tetrahydrofolate, which are essential cofactors for nucleotide synthesis and parasite DNA replication. The active metabolite cycloguanil also inhibits bacterial dihydrofolate reductase, enhancing antimalarial activity particularly against P. falciparum and P. vivax.

Is Proguanil safe to take with another drug?

For malaria prevention, take 2 tablets (200 mg) once daily with food or a milky drink. Start taking it 1-2 days before entering a malaria area, continue throughout your stay, and keep taking it for 4 weeks after you leave the area. Swallow the tablet whole with water — taking it after food helps reduce stomach upset. Proguanil is often used together with chloroquine for better protection.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for the one you missed.

• Mild stomach upset or nausea
• diarrhoea
• mouth ulcers (sores inside the mouth)
• mild hair loss with long-term use

Proguanil may reduce the effectiveness of the typhoid vaccine (oral type), so let your doctor know if you are being vaccinated. Antacids and magnesium-containing medicines can reduce how well proguanil works — space them at least 2 hours apart. Warfarin (blood-thinning medicine) effects may be increased when taken with proguanil, so your doctor may need to adjust your warfarin dose.

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tablets in their original packaging and far out of the reach of children.