Antibiotic and Antiparasitic combination (Fluoroquinolone + Nitroimidazole)
Brand of Ofloxacin; Ornidazole
Last reviewed June 2026
Who is this for?
Ofloxacin/Ornidazole is a combination of two medicines — Ofloxacin is an antibiotic that kills bacteria, while Ornidazole fights infections caused by tiny organisms called parasites and anaerobic bacteria (germs that grow without oxygen). Together, they tackle mixed infections more effectively than either one alone.
Inhibits bacterial DNA gyrase and topoisomerase IV (ofloxacin), preventing DNA replication and transcription, while disrupting anaerobic protozoal and bacterial DNA through nitro radical formation (ornidazole), effectively targeting aerobic bacteria and anaerobic organisms simultaneously.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
For adults, the usual dose is one tablet (Ofloxacin 200mg + Ornidazole 500mg) taken twice daily — morning and evening. Take it with or after food to reduce stomach upset. Swallow with a full glass of water. Complete the full course your doctor or pharmacist prescribed, usually 5 to 7 days, even if you start feeling better.
If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for it.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Always complete the full course even if you feel better after 2-3 days — stopping early can make the infection come back stronger and harder to treat. Buy only from licensed pharmacies and avoid roadside or market sellers, as fake versions of this drug are common in Nigeria. Do not share your prescription with anyone else, even if they have similar symptoms.
Do not drink alcohol while taking this drug — Ornidazole reacts badly with alcohol and can cause severe nausea, vomiting, and stomach cramps. Avoid taking antacids (like aluminum or magnesium-containing drugs) at the same time as this tablet, as they reduce its effectiveness — space them at least 2 hours apart. Be cautious if you are taking blood thinners like warfarin, as this drug can increase their effect.
Check your specific combination
Is it safe to take Ofloxacin; with your other drugs?
This drug is not safe during pregnancy and breastfeeding — do not use it unless your doctor specifically says it is necessary and there is no safer alternative.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the pack tightly closed and far from the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Oniflo 400 Tablet
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NAFDAC Number
B4-9520
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