How do you take Ibuprofen; Paracetamol; Caffeine?

Adults usually take 1 capsule or tablet 3 times a day, or as directed on the pack. Take it with food or after eating to protect your stomach. Swallow whole with a full glass of water. Do not take more than 3 capsules in 24 hours, and do not use for more than 3–5 days without seeing a doctor.

What are the side effects of Ibuprofen; Paracetamol; Caffeine?

Stomach upset or mild stomach pain, feeling slightly dizzy, nausea (feeling like you want to vomit), heartburn, and mild difficulty sleeping (because of the caffeine)

Who should not take Ibuprofen; Paracetamol; Caffeine?

People who are allergic to ibuprofen, paracetamol, caffeine, or aspirin. People with stomach ulcers or a history of stomach bleeding. People with severe liver or kidney problems. People with heart failure. Children under 12 years. People with asthma triggered by painkillers.

OTC

Painkiller (analgesic / anti-inflammatory combination)

Ibuprofen; Paracetamol; Caffeine

Q: What is Ibuprofen; Paracetamol; Caffeine used for?

Headache, body pain, toothache, menstrual pain (period pain), muscle pain, joint pain, backache, fever, cold and flu symptoms

Last reviewed July 2026

Who is this for?

For adults (18+). Standard adult dosing applies: see the How to Take tab for full instructions.

What is this drug?

This is a combination painkiller that contains three active ingredients: ibuprofen (which reduces pain and swelling), paracetamol (which reduces pain and fever), and caffeine (which boosts the effect of the other two and helps the medicine work faster).

How it works

Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin production to decrease pain, fever, and inflammation; paracetamol additionally acts on central pain pathways and temperature regulation centers; caffeine enhances analgesic efficacy by inhibiting phosphodiesterase and antagonizing adenosine receptors, increasing alertness and pain tolerance.

What is it used for?

Headachebody paintoothachemenstrual pain (period pain)muscle painjoint painbackachefevercold and flu symptoms

Browse by condition

Fever Headache & Migraine Cough & Cold Arthritis & Joint Pain Menstrual Pain Toothache & Dental Muscle Cramps & Spasms Pain Relief Osteoarthritis Moderate & Strong Pain Anti-inflammatory (NSAIDs)

Available Over The Counter

Get this from any pharmacy or chemist: no prescription needed.

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What to watch out for

Buy only from licensed pharmacies. Brands like Brustan Extra, Ibucap, Ibukuka, Tobez, or Vamacap Plus are commonly available in Nigeria, so look for trusted brands and check the expiry date. Do not combine with other paracetamol-containing drugs (like cold and flu medicines) as this can cause liver damage from overdose. If your pain or fever does not improve after 3 days, stop and see a doctor rather than increasing the dose on your own.

Common Side Effects

Stomach upset or mild stomach pain
feeling slightly dizzy
nausea (feeling like you want to vomit)
heartburn
and mild difficulty sleeping (because of the caffeine)

Serious Side Effects

Severe stomach pain
vomiting blood or passing dark/black stool (this could mean stomach bleeding, so go to the hospital immediately). Signs of allergic reaction like swelling of the face
lips
or throat
or difficulty breathing
so seek emergency help right away.

Drug Interactions

Avoid taking this with alcohol, as it increases the risk of stomach bleeding and liver damage. Do not take alongside other painkillers like aspirin, diclofenac, or another paracetamol product as you may overdose. If you are on blood-thinning medicines (like warfarin), consult your doctor before using this drug.

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Pregnancy & Breastfeeding Warning

This combination is not recommended during pregnancy, especially in the last trimester, and should be used with caution during breastfeeding. Always consult your doctor or pharmacist first.

Who Should NOT Take This

People who are allergic to ibuprofen
paracetamol
caffeine
or aspirin. People with stomach ulcers or a history of stomach bleeding. People with severe liver or kidney problems. People with heart failure. Children under 12 years. People with asthma triggered by painkillers.

How to Store

Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the container tightly closed and always store out of reach of children.

For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.