NSAID (Painkiller/Anti-inflammatory) + Stomach Protector (Prostaglandin)
Brand of Diclofenac Sodium; Misoprostol
Last reviewed June 2026
Who is this for?
This is a combination drug that contains diclofenac sodium (a strong painkiller and anti-inflammatory medicine) and misoprostol (a medicine that protects your stomach lining from the harsh effects of the painkiller). It works by reducing pain and swelling while preventing stomach ulcers that painkillers can cause.
Inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis and thereby decreasing pain and inflammation; misoprostol activates prostaglandin E1 receptors in the gastric mucosa, promoting protective mucus secretion and reducing acid production to prevent NSAID-induced ulceration.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
The usual dose for adults is one tablet taken 2 to 3 times daily, depending on your doctor's prescription. Take it with food or immediately after eating to reduce stomach upset. Swallow the tablet whole — do not crush, chew, or break it. Follow your doctor's instructions strictly on how many tablets and how often.
If you miss a dose, take it as soon as you remember — but if it is almost time for your next dose, skip the missed one and continue your normal schedule. Never take two tablets at once to make up for a missed dose.
Only buy from registered pharmacies — do not purchase from roadside vendors or open markets, as fake versions of this drug are common in Nigeria. Do not share this medication with anyone, especially women of childbearing age, because of the serious pregnancy risks. If you experience persistent diarrhea lasting more than a few days, contact your doctor — do not just manage it at home.
Avoid taking with other painkillers like ibuprofen or aspirin as this increases the risk of stomach bleeding. Blood-thinning drugs like warfarin can become more dangerous when combined with this medicine. Avoid alcohol completely — it greatly increases your risk of stomach ulcers and bleeding.
Check your specific combination
Is it safe to take Diclofenac with your other drugs?
This drug is STRICTLY NOT SAFE during pregnancy — the misoprostol component can cause miscarriage, premature birth, or serious harm to the baby, and it should also be avoided during breastfeeding.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid storing near windows or in cars. Keep the tablets in their original pack and far away from children. Do not store in the bathroom where humidity is high.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Zytrotec 75 mg/200 mcg Tablet
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NAFDAC Number
B4-5893
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