Podophyllin Cream 20 g (0.15% w/w) Cream (Podophyllotoxin) — Uses, Dosage & NAFDAC

Who is this for?

What is this drug?

Podophyllotoxin is a plant-based medicine that works by stopping the growth of abnormal skin cells, specifically wart cells, causing them to die and fall off over time.

What is it used for?

Genital warts (warts around the private parts)external condylomata (soft warts caused by a virus)

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Genital Warts STIs & Sexual Health Skin Infections Topical Antibiotics & Antiseptics Wound Care & Antiseptics Chickenpox & Shingles Eczema & Skin Rashes

How it works

Binds to tubulin and inhibits microtubule assembly in the metaphase of cell division, causing arrest of mitosis and leading to necrosis of wart tissue infected with human papillomavirus (HPV).

Prescription Required

You need a doctor's prescription to buy this drug.

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How to take this drug

Apply a thin layer of the cream directly onto the wart twice a day (morning and night) for 3 days, then stop for 4 days. This makes one treatment cycle. You can repeat for up to 4 cycles if the wart is still there. Use your finger or a small applicator to dab it only on the wart — avoid the healthy skin around it. Wash your hands well after applying.

What if I Miss a Dose?

If you forget to apply it, just apply it as soon as you remember. If it is almost time for your next application, skip the missed one and continue your normal schedule. Do not apply extra to make up for it.

What to watch out for

Only buy Podophyllin Cream from registered pharmacies — do not buy from roadside vendors or open markets as fake products can burn or damage your skin badly. Apply it only on the wart itself and not on surrounding healthy skin — you can apply petroleum jelly (Vaseline) around the wart to protect normal skin. Genital warts are caused by a virus (HPV), so even after the warts clear, see a doctor about preventing spread to your partner.

Common Side Effects

Burning or stinging feeling on the skin where you applied it
redness and soreness around the treated area
skin peeling or flaking at the wart site
mild itching

Serious Side Effects

Severe skin ulcers or deep wounds that do not heal at the application site
signs of allergic reaction such as swelling of the face or difficulty breathing
excessive bleeding or blistering of the treated area — see a doctor immediately if any of these happen.

Drug Interactions

Do not use other wart removal products (like salicylic acid-based removers) on the same area at the same time as it can cause severe skin damage. Avoid using harsh soaps, perfumes, or body sprays directly on the treated area. There are no known major food or alcohol interactions, but alcohol may slow healing in general.

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Pregnancy & Breastfeeding Warning

Podophyllotoxin is NOT safe during pregnancy or breastfeeding — it can harm the unborn baby, so do not use it if you are pregnant, planning to become pregnant, or breastfeeding.

Who Should NOT Take This

People who are allergic to podophyllotoxin or any ingredient in the cream
pregnant or breastfeeding women
children
people with open wounds or bleeding warts
people with warts inside the vagina
anus
or urethra (it is only for external warts).

How to Store

Store at room temperature below 25°C in a cool, dry place away from direct sunlight and heat — this is important in Nigeria's hot climate. Keep the tube tightly closed and far away from children. Do not store in the bathroom where humidity is high.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.

Podophyllin Cream 20 g (0.15% w/w)