Zedex D Tablet (Paracetamol; Doxylamine; Dextromethorphan) — Uses, Dosage & NAFDAC

Who is this for?

What is this drug?

This is a combination medicine that contains three active ingredients: paracetamol (a painkiller and fever reducer), doxylamine (an antihistamine that helps dry up a runny nose and helps you sleep), and dextromethorphan (a cough suppressant that calms dry cough). Together, they work to relieve cold and flu symptoms.

What is it used for?

Cold and flu symptomsdry coughrunny or blocked nosesneezingbody painheadachefeversore throat

Browse by condition

Cold & Flu Remedies Cough & Cold Allergies

How it works

Inhibits COX-1 and COX-2 enzymes to reduce prostaglandin synthesis, thereby decreasing fever, pain, and inflammation; blocks H1 histamine receptors to reduce nasal congestion and sneezing; and suppresses the cough reflex by acting on the cough centre in the medulla oblongata.

Available Over The Counter

Get this from any pharmacy or chemist — no prescription needed.

Quick Interaction Check

Is Paracetamol; safe to take with another drug?

Check with multiple drugs →

Explore this drug

How to take this drug

For adults, take the recommended dose (usually 1-2 tablets or the measured dose of syrup) every 6-8 hours as needed. Do not take more than 4 doses in 24 hours. You can take it with or without food. Because it causes drowsiness, it is best taken at night or when you do not need to drive or operate machines.

What if I Miss a Dose?

Since this medicine is taken only when you have symptoms, there is no strict schedule. If you forget a dose, take it when you remember, but do not double up. Just make sure you wait at least 6 hours before the next dose.

What to watch out for

Do not combine this medicine with other paracetamol products — many cold and flu medicines already contain paracetamol, and taking too much can damage your liver. This medicine makes you very drowsy, so do not drive, ride okada, or operate heavy machinery after taking it. Buy only from reputable pharmacies — products like Zedex D should come in proper, sealed packaging with a valid NAFDAC number.

Common Side Effects

Feeling very sleepy or drowsy
dizziness
dry mouth
mild stomach upset
blurred vision

Serious Side Effects

Severe allergic reaction such as swelling of the face
lips or throat and difficulty breathing — go to the hospital immediately. Yellowing of the eyes or skin (which may mean liver damage
especially if you took too much paracetamol) — seek urgent medical help.

Drug Interactions

Do not drink alcohol while taking this medicine — alcohol increases drowsiness and can seriously damage your liver when combined with paracetamol. Avoid taking other paracetamol-containing medicines (like Tylenol, Hedex, or Boska) at the same time, as this can lead to overdose. Do not combine with other cough and cold medicines or sedatives without asking a pharmacist.

Check your specific combination

Is it safe to take Paracetamol; with your other drugs?

Check →

Pregnancy & Breastfeeding Warning

This combination is not recommended during pregnancy or breastfeeding — consult your doctor before taking it, as some of the ingredients may affect your baby.

Who Should NOT Take This

People who are allergic to paracetamol
doxylamine
or dextromethorphan. People with serious liver disease or kidney problems. People currently taking MAO inhibitor medicines (a type of antidepressant). People with chronic breathing problems like asthma should use with caution. Children under 12 years should avoid it unless directed by a doctor.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the container tightly closed to protect from humidity. Always keep it out of the reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.

Zedex D