Painkiller and Antihistamine (Night-time pain and cold relief)
Last reviewed July 2026
Who is this for?
This is a combination drug that contains paracetamol (a painkiller and fever reducer) and diphenhydramine (an antihistamine that helps you sleep and relieves allergies). Paracetamol works by blocking pain signals in the brain, while diphenhydramine reduces allergic reactions and causes drowsiness to help you rest at night.
Inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis to alleviate pain and fever, while blocking H1 histamine receptors to suppress allergic symptoms and promote sedation via central nervous system depression.
Available Over The Counter
Get this from any pharmacy or chemist: no prescription needed.
Explore this drug
Since this drug is usually taken only at night when you have symptoms, there is no strict dosing schedule. If you forget to take it at bedtime, skip it rather than taking it in the middle of the night or morning, as it will make you drowsy during the day. Take it the next night if you still need it.
Do not drive, operate machinery, or do anything requiring alertness after taking this drug, as it will make you very sleepy. Buy only from reputable pharmacies and check the expiry date, especially for brands like Emzor Para Night, Bioramol Night, or Novadex Night Caplet. Avoid roadside sellers. Do not take more than the recommended dose of paracetamol (no more than 4g per day from all sources combined) to protect your liver.
Do not drink alcohol while taking this drug, as alcohol increases drowsiness and raises the risk of liver damage from paracetamol. Avoid taking other paracetamol-containing products (like Boska, Procold, or Combiflam) at the same time to prevent overdose. Do not combine with other drowsy-making drugs like chlorpheniramine, promethazine, or sleeping tablets, as it can cause extreme drowsiness.
Check your specific combination
Is it safe to take Paracetamol; with your other drugs?
Consult your doctor before taking this drug if you are pregnant or breastfeeding. While paracetamol alone is generally considered safe, diphenhydramine may not be safe, especially in the third trimester or while nursing.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the container tightly closed to protect from humidity. Always keep out of the reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.