Painkiller and fever reducer (analgesic/antipyretic with caffeine adjuvant)
Last reviewed July 2026
Who is this for?
Paracetamol with Caffeine is a combination painkiller where the paracetamol reduces pain and fever by acting on the brain's pain and temperature centres, while the caffeine boosts the painkiller effect and helps you feel more alert.
Inhibits central prostaglandin synthesis by suppressing COX-1 and COX-2 enzymes in the hypothalamus, reducing pain perception and lowering the febrile set point; caffeine enhances analgesic efficacy by inhibiting phosphodiesterase and adenosine receptors, promoting CNS stimulation and improving drug absorption.
Available Over The Counter
Get this from any pharmacy or chemist: no prescription needed.
Explore this drug
Since this drug is taken only when you have pain or fever, there is no strict schedule. Simply take your next dose when you need it, but make sure you wait at least 4 hours between doses. Never double up to make up for a missed dose.
Do not combine with other paracetamol-containing products because many Nigerian cold, flu, and pain drugs already contain paracetamol, and taking too much can damage your liver without you realising. Buy only from licensed pharmacies and look for trusted brands like Forpain, Buskakris, Exadon, or Bioramol Extra; avoid buying loose tablets from roadside sellers or bus hawkers. If your pain or fever does not improve after 3 days, see a doctor because it could be malaria, typhoid, or something that needs proper diagnosis.
Avoid drinking alcohol while taking this drug because alcohol and paracetamol together can seriously damage your liver. Be careful with other medicines that contain paracetamol (like cold and flu remedies) so you don't accidentally take too much. Caffeine in coffee, tea, kola nut, or energy drinks can add up and make you feel shaky or unable to sleep.
Check your specific combination
Is it safe to take Paracetamol; with your other drugs?
Consult your doctor or pharmacist before taking this drug if you are pregnant or breastfeeding. Plain paracetamol alone is generally preferred during pregnancy, but the caffeine component needs medical guidance.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the pack tightly closed to protect from moisture and always keep it out of the reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.