Muscle relaxant and Painkiller combination
Last reviewed July 2026
Who is this for?
This is a combination drug that contains orphenadrine (a muscle relaxant) and paracetamol (a painkiller). Orphenadrine works by relaxing tight, stiff muscles while paracetamol reduces pain and fever, so together they relieve pain caused by muscle spasms and tension.
Blocks central cholinergic pathways and reduces muscle tone through anticholinergic activity, while paracetamol inhibits COX enzymes in the central nervous system to reduce pain perception and fever, providing combined relief of musculoskeletal pain and muscle spasticity.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for the one you missed.
This drug can make you drowsy, so avoid driving or operating heavy machinery after taking it. Do not combine with other paracetamol products, as many Nigerian cold and pain drugs already contain paracetamol, and taking too much can seriously damage your liver. Always buy from a licensed pharmacy, not roadside sellers, to ensure you get genuine medication.
Avoid drinking alcohol while taking this drug as it can make drowsiness and dizziness much worse. Be careful if you are taking other drugs that cause sleepiness such as antihistamines (allergy drugs like chlorpheniramine or Piriton). Do not combine with other paracetamol-containing drugs (like Panadol or cold remedies) as this can lead to paracetamol overdose which damages the liver.
Check your specific combination
Is it safe to take Orphenadrine with your other drugs?
This drug is not recommended during pregnancy or breastfeeding unless your doctor specifically prescribes it, so consult your doctor before use.
Store in a cool, dry place away from direct sunlight and heat, as Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep in the original pack and always store out of reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.