NSAID (Non-Steroidal Anti-Inflammatory Drug) / Strong Painkiller
Last reviewed July 2026
Who is this for?
Indometacin (also called Indomethacin) is a strong anti-inflammatory painkiller that works by blocking chemicals in your body that cause pain, swelling, and fever. It belongs to a group of drugs called NSAIDs (non-steroidal anti-inflammatory drugs).
Inhibits both COX-1 and COX-2 enzymes, reducing prostaglandin and thromboxane synthesis to suppress pain, inflammation, and fever across musculoskeletal and inflammatory conditions.
Severe joint pain, arthritis, rheumatism, gout pain, back pain, muscle and bone pain, swelling of joints, menstrual pain, body pain that doesn't respond to milder painkillers
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember, but only if it is not close to your next dose. If it is almost time for the next one, just skip the missed dose. Never take a double dose to make up for it.
Always buy from a licensed pharmacy, avoid buying Indomethacin from roadside vendors or open markets as fake or expired drugs are common. Do not use this drug for everyday body pain or as a regular painkiller, as it is a strong medicine meant for serious inflammation. If you notice stomach pain or dark stool while using it, stop and see a doctor immediately.
Avoid taking with other painkillers like ibuprofen, diclofenac, or aspirin as this increases the risk of stomach bleeding. If you are on blood pressure drugs like lisinopril or amlodipine, indometacin can reduce their effect. Avoid alcohol completely, as it seriously increases your chance of stomach ulcer and bleeding.
Check your specific combination
Is it safe to take Indometacin with your other drugs?
Indometacin is NOT safe during pregnancy, especially in the last three months, and should be avoided during breastfeeding. Talk to your doctor before using it if you are pregnant or nursing.
Store in a cool, dry place away from direct sunlight and heat, as Nigerian weather can damage medicines fast. Keep the pack tightly closed and far from the reach of children. Do not store in the bathroom where there is moisture.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.