Antineoplastic (cancer-fighting medicine) / Disease-modifying agent for sickle cell disease
Brand of Hydroxycarbamide
Last reviewed June 2026
Who is this for?
Hydroxycarbamide (also called hydroxyurea) is a medicine that works by slowing down the growth of certain cells in the body, especially fast-growing cells like cancer cells and abnormal blood cells. For sickle cell disease, it helps the body make healthier red blood cells that are less likely to sickle and block blood vessels.
Inhibits ribonucleotide reductase, reducing deoxyribonucleotide synthesis and thereby suppressing DNA replication in rapidly dividing cells; increases fetal haemoglobin (HbF) production, reducing sickling and vaso-occlusive episodes in sickle cell disease.
Prescription Required
You need a doctor's prescription to buy this drug.
Is Hydroxycarbamide safe to take with another drug?
Check with multiple drugs →Explore this drug
Your doctor will decide the exact dose based on your condition and body weight. For sickle cell disease, the usual starting dose is about 15mg per kilogram body weight per day, taken once daily. Swallow the capsule or tablet whole with a full glass of water. You can take it with or without food. Your doctor may gradually increase the dose over time based on your blood test results.
If you miss a dose, skip it and take the next dose at the usual time. Do not take a double dose to make up for the one you missed. If you are not sure what to do, call your doctor or pharmacist.
This is a very serious prescription medicine — never buy it from roadside sellers or use someone else's prescription. You must do regular blood tests (at least monthly) while taking this drug so your doctor can check your blood cell counts. Handle the capsules or tablets carefully — do not open, crush, or break them, and wash your hands after touching them.
Avoid taking hydroxycarbamide with other medicines that lower blood cell counts (like some HIV drugs such as stavudine or didanosine) as this increases the risk of dangerous side effects. Alcohol should be avoided as it can worsen liver problems and side effects. Always tell your doctor about all other medicines you are taking, including herbal remedies and supplements.
Check your specific combination
Is it safe to take Hydroxycarbamide with your other drugs?
Hydroxycarbamide is NOT safe during pregnancy as it can seriously harm the unborn baby, and it should NOT be used while breastfeeding — both men and women taking this drug should use reliable contraception and consult their doctor before planning a pregnancy.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in cars or near windows. Keep the container tightly closed to protect from moisture. Keep far away from children as this medicine can be very dangerous if taken by someone it was not prescribed for.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Hydroxyurea 1000 mg Film Coated Tablets
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NAFDAC Number
A4-100408
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