Painkiller (Opioid analgesic + Non-opioid analgesic combination)
Last reviewed June 2026
Who is this for?
This is a combination painkiller that contains two medicines — Tramadol (a strong pain reliever that works on pain signals in the brain) and Paracetamol (which reduces pain and fever). Together, they provide stronger pain relief than either one alone.
Binds to opioid receptors (μ, δ, κ) and inhibits monoamine reuptake (noradrenaline and serotonin), while paracetamol inhibits COX enzymes and modulates central pain perception, providing synergistic analgesia for moderate to severe pain.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Adults usually take 1 to 2 tablets every 4 to 6 hours as needed for pain, but do not take more than 8 tablets in a day. Swallow the tablet whole with water — you can take it with or without food, but taking it with food can reduce stomach upset. Do not crush or chew the tablet.
Since this medicine is usually taken only when you have pain, there is no strict schedule. If your doctor asked you to take it regularly and you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one — never double up.
This is a controlled substance — do not buy from roadside sellers or unauthorized vendors, as fake versions are common in Nigeria and can be very dangerous. Do not share this medicine with anyone else, even if they have similar pain. Do not take it for longer than your doctor prescribed, as Tramadol can become addictive.
Do not drink alcohol while taking this medicine — it can cause dangerous drowsiness, breathing problems, or even death. Avoid taking it with other medicines that make you sleepy like antihistamines (e.g. Piriton) or sleeping pills. Do not combine with other paracetamol-containing drugs (like Boska, Procold, or Tylenol) as this can damage your liver.
Check your specific combination
Is it safe to take Tramadol with your other drugs?
This drug is NOT safe during pregnancy, especially in the later months, and should be avoided while breastfeeding — consult your doctor before use.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be hot, so avoid leaving it in your car or near windows. Keep it in its original pack and far away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.