Antidiabetic (DPP-4 Inhibitor)
Brand of Sitagliptin
Last reviewed June 2026
Who is this for?
Sitagliptin is a diabetes medicine that works by helping your body produce more insulin after you eat and reducing the amount of sugar your liver releases into your blood, so your blood sugar stays under control.
Inhibits dipeptidyl peptidase-4 (DPP-4) enzyme, preventing degradation of incretin hormones (GLP-1 and GIP) and thereby prolonging their action to increase insulin secretion and decrease glucagon release in response to meals, resulting in improved blood glucose control.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
The usual dose is one 100 mg tablet once a day. You can take it with or without food — just try to take it at the same time every day so you don't forget. Your doctor may start you on 50 mg if you have kidney problems. Continue taking it even when you feel fine, as diabetes needs long-term management.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.
Always buy your diabetes medicine from a licensed pharmacy — do not buy from roadside sellers or unregistered shops, as fake drugs are common and can be dangerous. Do not stop taking this medicine because you feel fine; diabetes is a long-term condition that needs continuous management. Monitor your blood sugar regularly and watch for signs of low blood sugar like dizziness, sweating, shaking, or confusion, especially if you are taking other diabetes drugs alongside sitagliptin.
If you are taking insulin or other diabetes medicines like glimepiride, combining them with sitagliptin can cause your blood sugar to drop too low — your doctor may need to adjust the dose. Be careful with alcohol as it can make your blood sugar unpredictable when combined with diabetes medicines. Let your doctor know if you are taking digoxin (a heart medicine) as sitagliptin may increase its levels in your body.
Check your specific combination
Is it safe to take Sitagliptin with your other drugs?
Sitagliptin is not recommended during pregnancy or breastfeeding — consult your doctor immediately if you are pregnant, planning to get pregnant, or breastfeeding so they can switch you to a safer option.
Store in a cool, dry place away from direct sunlight and heat — this is especially important in hot Nigerian weather. Keep in the original pack and away from moisture. Always keep out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Sitagliptin 100 mg Tablet
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NAFDAC Number
A4-101226
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