How do you take Pseudoephedrine Hydrochloride; Triprolidine?

For adults, take 1 tablet or capsule every 4 to 6 hours, or as directed on the pack. You can take it with or without food, but taking it with a little food may reduce stomach upset. Do not take more than 4 doses in 24 hours. Popular brands in Nigeria include Actifed Cold Tablets, Sinufed, G-Fed, and Nocin.

What are the side effects of Pseudoephedrine Hydrochloride; Triprolidine?

Feeling sleepy or drowsy, dry mouth, slight dizziness, mild headache, feeling restless or unable to sleep (especially from the pseudoephedrine part)

Who should not take Pseudoephedrine Hydrochloride; Triprolidine?

People with high blood pressure, severe heart disease, overactive thyroid, or glaucoma (eye pressure problem) should not take this drug. Do not use if you are taking MAO inhibitor drugs (a type of antidepressant). People allergic to pseudoephedrine or triprolidine should avoid it. Children under 2 years should not use it without a doctor's prescription.

OTC

Decongestant and Antihistamine combination

Pseudoephedrine Hydrochloride; Triprolidine

Q: What is Pseudoephedrine Hydrochloride; Triprolidine used for?

Cold and catarrh, blocked nose, runny nose, sneezing, watery and itchy eyes, sinus congestion, hay fever, allergic reactions affecting the nose

Last reviewed July 2026

Who is this for?

For adults (18+). Standard adult dosing applies: see the How to Take tab for full instructions.

What is this drug?

This is a combination drug containing pseudoephedrine (a decongestant that opens up blocked nose and sinuses) and triprolidine (an antihistamine that stops sneezing, runny nose, and itchy eyes). Together, they relieve cold and allergy symptoms by reducing swelling in your nasal passages and blocking the body's allergic reactions.

How it works

Activates alpha-1 adrenergic receptors on nasal blood vessels causing vasoconstriction and reducing congestion, while blocking H1 histamine receptors to suppress allergic symptoms including rhinorrhea, sneezing, and pruritus.

What is it used for?

Cold and catarrhblocked noserunny nosesneezingwatery and itchy eyessinus congestionhay feverallergic reactions affecting the nose

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Fever Cough & Cold Allergies Sinus & Nasal Cold & Flu Remedies

Available Over The Counter

Get this from any pharmacy or chemist: no prescription needed.

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What to watch out for

This drug can make you very drowsy, so do not drive or operate machines after taking it, especially the first time. Buy only from reputable pharmacies and avoid roadside sellers, as fake versions are common. If your symptoms do not improve after 5 to 7 days, see a doctor rather than continuing to self-medicate.

Common Side Effects

Feeling sleepy or drowsy
dry mouth
slight dizziness
mild headache
feeling restless or unable to sleep (especially from the pseudoephedrine part)

Serious Side Effects

Fast or pounding heartbeat: see a doctor immediately. Difficulty breathing or severe allergic reaction (swelling of face, lips, or throat): go to the hospital right away. Difficulty passing urine or unusual confusion also needs urgent medical attention.

Drug Interactions

Do not take with alcohol, as it will make the drowsiness much worse and can be dangerous. Avoid using with other cold or cough medicines that already contain decongestants or antihistamines, as this can lead to overdose. If you are taking medicines for high blood pressure (like amlodipine or lisinopril), talk to your doctor first because pseudoephedrine can raise blood pressure.

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Pregnancy & Breastfeeding Warning

This drug is not recommended during pregnancy or breastfeeding unless your doctor specifically says it is okay. Consult your doctor before using it.

Who Should NOT Take This

People with high blood pressure
severe heart disease
overactive thyroid
or glaucoma (eye pressure problem) should not take this drug. Do not use if you are taking MAO inhibitor drugs (a type of antidepressant). People allergic to pseudoephedrine or triprolidine should avoid it. Children under 2 years should not use it without a doctor's prescription.

How to Store

Store in a cool, dry place away from direct sunlight and heat, which is especially important in Nigeria's hot climate. Keep the bottle or pack tightly closed to avoid moisture. Always keep out of reach of children.

For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.