Mixanal Caplet Tablet (Paracetamol; Guaranine) — Uses, Dosage & NAFDAC

Who is this for?

What is this drug?

This is a combination painkiller and energy-boosting drug that contains paracetamol (which reduces pain and fever) and guaranine (caffeine from guarana, a natural stimulant that helps the paracetamol work faster and also reduces tiredness).

What is it used for?

Headachebody painmuscle painfevercold and flu symptomstoothachemenstrual paintiredness and fatigue

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Pain Relief

How it works

Inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis to relieve pain and fever, while caffeine (guaranine) acts as a non-selective adenosine receptor antagonist to enhance analgesia and promote wakefulness by increasing CNS stimulation.

Available Over The Counter

Get this from any pharmacy or chemist — no prescription needed.

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How to take this drug

Adults can take 1 to 2 caplets every 4 to 6 hours as needed. Do not take more than 8 caplets in 24 hours. You can take it with or without food, but taking it with a little food can help if it upsets your stomach. Swallow with a full glass of water.

What if I Miss a Dose?

Since this drug is taken only when you have pain or fever, there is no strict schedule. Simply take your next dose when you need it, but make sure you wait at least 4 hours between doses. Never double up to make up for a missed dose.

What to watch out for

Do not combine this with other paracetamol-containing drugs like cold and flu medicines — many Nigerian over-the-counter drugs already contain paracetamol, so check the label to avoid overdose. Buy only from registered pharmacies and not roadside vendors, as fake drugs are common. Avoid taking this drug late at night as the caffeine can keep you awake.

Common Side Effects

Trouble sleeping or restlessness (because of the caffeine)
feeling jittery or shaky
stomach upset or mild nausea
fast heartbeat
dizziness

Serious Side Effects

Signs of liver damage such as yellowing of the eyes or skin
dark urine
or severe stomach pain — go to the hospital immediately. Severe allergic reaction with skin rash
swelling of the face or throat
or difficulty breathing — seek emergency care right away.

Drug Interactions

Avoid drinking alcohol while using this drug, as both alcohol and paracetamol can damage your liver. Be careful with coffee, kola nut, or energy drinks since the guaranine is already caffeine — too much caffeine can cause heart racing and anxiety. If you are taking blood-thinning drugs like warfarin, talk to your doctor first as paracetamol can affect how they work.

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Pregnancy & Breastfeeding Warning

Pregnant and breastfeeding women should consult their doctor before using this drug, as the caffeine component can affect the baby and plain paracetamol alone may be a safer choice.

Who Should NOT Take This

People who are allergic to paracetamol or caffeine
people with serious liver disease or liver problems
people with severe heart conditions or irregular heartbeat
people with anxiety disorders
children under 12 years
and anyone who drinks alcohol heavily.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep it in its original container and away from children at all times.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.

Mixanal Caplet