Nise Plus Syrup Syrup (Paracetamol; Chlorphenamine Maleate; Ascorbic Acid) — Uses, Dosage & NAFDAC

Who is this for?

What is this drug?

This is a combination drug that contains paracetamol (a painkiller and fever reducer), chlorphenamine (an antihistamine that reduces allergic symptoms like sneezing and runny nose), and vitamin C (which helps support your immune system). Together, they work to relieve cold and flu symptoms.

What is it used for?

Coldflucatarrhsneezingrunny nosebody painfeverheadachewatery eyessore throat

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How it works

Inhibits COX-1 and COX-2 enzymes to reduce prostaglandin-mediated pain and fever; blocks H1 histamine receptors to suppress allergic symptoms and congestion; and replenishes ascorbic acid to enhance immune function and reduce symptom duration.

Available Over The Counter

Get this from any pharmacy or chemist — no prescription needed.

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How to take this drug

For adults, the usual dose is 1-2 tablets taken 3 to 4 times a day, or as directed on the pack. You can take it with or without food, but taking it with food can help if it upsets your stomach. Do not take more than 8 tablets in 24 hours. For the syrup form like Nise Plus Syrup, follow the dosage on the label or as your pharmacist advises.

What if I Miss a Dose?

If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, just skip the missed one and continue as normal. Do not take a double dose to make up for the one you missed.

What to watch out for

This drug causes drowsiness, so avoid driving okada, keke, or cars after taking it. Do not combine with other cold and flu drugs that also contain paracetamol — check the ingredients to avoid overdose. Buy only from reputable pharmacies and check the expiry date, especially with syrups like Nise Plus.

Common Side Effects

Feeling sleepy or drowsy (this is very common with this drug)
dry mouth
dizziness
slight blurred vision
mild stomach upset

Serious Side Effects

Severe allergic reaction such as swelling of the face
lips or throat — go to the hospital immediately. Yellowing of the eyes or skin (which could mean liver damage
especially if you take too much paracetamol) — stop the drug and see a doctor right away.

Drug Interactions

Avoid drinking alcohol while taking this drug — alcohol increases drowsiness and can also damage your liver together with paracetamol. Do not take this alongside other paracetamol-containing drugs (like Boska, Procold, or Combiflam) as too much paracetamol can damage your liver. If you are taking blood-thinning drugs like warfarin, talk to your doctor first.

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Pregnancy & Breastfeeding Warning

If you are pregnant or breastfeeding, consult your doctor or pharmacist before taking this drug — some of the ingredients may not be safe, especially in the first trimester and close to delivery.

Who Should NOT Take This

People who are allergic to paracetamol
chlorphenamine
or vitamin C should not take this drug. People with serious liver or kidney problems should avoid it. People who operate heavy machinery or drive should be careful because it causes drowsiness. Do not give to children under 2 years without a doctor's guidance.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the container tightly closed and always store out of reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.

Nise Plus Syrup