Painkiller, Antihistamine, and Vitamin supplement combination (Cold and Flu relief)
Last reviewed June 2026
Who is this for?
This is a combination drug that contains paracetamol (a painkiller and fever reducer), chlorphenamine (an antihistamine that reduces allergic symptoms like sneezing and runny nose), and vitamin C (which helps support your immune system). Together, they work to relieve cold and flu symptoms.
Inhibits COX-1 and COX-2 enzymes to reduce prostaglandin-mediated pain and fever; blocks H1 histamine receptors to suppress allergic symptoms and congestion; and replenishes ascorbic acid to enhance immune function and reduce symptom duration.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
For adults, the usual dose is 1-2 tablets taken 3 to 4 times a day, or as directed on the pack. You can take it with or without food, but taking it with food can help if it upsets your stomach. Do not take more than 8 tablets in 24 hours. For the syrup form like Nise Plus Syrup, follow the dosage on the label or as your pharmacist advises.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, just skip the missed one and continue as normal. Do not take a double dose to make up for the one you missed.
This drug causes drowsiness, so avoid driving okada, keke, or cars after taking it. Do not combine with other cold and flu drugs that also contain paracetamol — check the ingredients to avoid overdose. Buy only from reputable pharmacies and check the expiry date, especially with syrups like Nise Plus.
Avoid drinking alcohol while taking this drug — alcohol increases drowsiness and can also damage your liver together with paracetamol. Do not take this alongside other paracetamol-containing drugs (like Boska, Procold, or Combiflam) as too much paracetamol can damage your liver. If you are taking blood-thinning drugs like warfarin, talk to your doctor first.
Check your specific combination
Is it safe to take Paracetamol; with your other drugs?
If you are pregnant or breastfeeding, consult your doctor or pharmacist before taking this drug — some of the ingredients may not be safe, especially in the first trimester and close to delivery.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the container tightly closed and always store out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.