Proton Pump Inhibitor + Anti-emetic (Stomach acid reducer + Anti-vomiting)
Last reviewed June 2026
Who is this for?
This is a combination drug containing omeprazole (which reduces the amount of acid your stomach produces) and domperidone (which helps stop nausea, vomiting, and moves food through your stomach faster). Together, they treat stomach acid problems and the discomfort that comes with them.
Inhibits the H+/K+-ATPase proton pump in gastric parietal cells, reducing gastric acid secretion, while domperidone blocks dopamine receptors in the chemoreceptor trigger zone and enhances gastric motility, thereby alleviating nausea, vomiting, and improving gastric emptying.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Take 1 capsule once or twice daily, usually 30 minutes before meals — preferably before breakfast and dinner. Swallow the capsule whole with water; do not crush or chew it. Your doctor will tell you how long to use it, but a common course is 2 to 4 weeks.
If you miss a dose, take it as soon as you remember — but if it's almost time for your next dose, just skip the missed one and continue as normal. Do not take two capsules at once to make up for it.
Buy only from a registered pharmacy — do not purchase from roadside sellers or open markets, as fake drugs are common. Do not use this drug for more than 4 weeks without seeing a doctor, as long-term use of omeprazole can cause other problems. If your symptoms do not improve after a week or get worse, see a doctor instead of increasing the dose yourself.
Avoid taking with ketoconazole or itraconazole (antifungal drugs often used for skin infections) as they can interact badly with domperidone. Be careful if you are taking blood thinners like warfarin, as omeprazole can affect how they work. Avoid alcohol, as it increases stomach acid and can worsen your condition.
Check your specific combination
Is it safe to take Omeprazole; with your other drugs?
This combination is not recommended during pregnancy or breastfeeding unless your doctor specifically says it is necessary — consult your doctor before using it.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep it in the original pack and far out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.