Sitagliptin/Metformin 50 mg/500 mg Tablet

Who is this for?

This is a combination diabetes tablet that contains two medicines — Sitagliptin and Metformin — working together to lower blood sugar. Metformin reduces the amount of sugar your liver releases and helps your body use insulin better, while Sitagliptin helps your body produce more insulin after meals and reduces excess sugar production.

Inhibits dipeptidyl peptidase-4 (DPP-4) enzyme to increase incretin levels and enhance insulin secretion, while simultaneously inhibiting hepatic gluconeogenesis and improving insulin sensitivity through AMP-activated protein kinase activation.

Is Metformin safe to take with another drug?

Usually taken twice daily with meals — one tablet in the morning and one in the evening. Always take it with food to reduce stomach upset and help the medicine work better. Your doctor will decide the right strength based on your current blood sugar level. Swallow the tablet whole with water; do not crush or chew, especially the extended-release (ER) types like Instadip M-ER.

If you miss a dose, take it as soon as you remember — but only if it is close to your next mealtime. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Never take two tablets at once to make up for a missed dose.

• Stomach upset or diarrhea
• nausea or feeling like vomiting
• gas or bloating
• headache
• runny or blocked nose. These are usually mild and may improve as your body adjusts to the medicine.

Avoid drinking alcohol while on this medicine as it increases the risk of a dangerous condition called lactic acidosis and can cause your blood sugar to drop too low. Be careful when taking this alongside other diabetes medicines like insulin or glimepiride as it may cause your sugar to drop dangerously low. Inform your doctor if you are taking any heart or blood pressure medicines, especially diuretics (water tablets).

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tablets in their original pack and far out of reach of children.