Kombiglyze-XR 2.5 mg/1000 mg Tablets

Who is this for?

This is a combination tablet containing two diabetes medicines — Metformin and Saxagliptin — that work together to lower blood sugar. Metformin reduces the amount of sugar your liver releases and helps your body use insulin better, while Saxagliptin helps your body produce more insulin after meals and reduces excess sugar production.

Inhibits hepatic glucose production and increases peripheral insulin sensitivity by activating AMP-activated protein kinase (AMPK), while saxagliptin inhibits dipeptidyl peptidase-4 (DPP-4) to increase incretin levels, thereby enhancing glucose-dependent insulin secretion and reducing glucagon release.

Is Metformin safe to take with another drug?

Take one tablet once daily with your evening meal. Swallow the tablet whole — do not crush, chew, or break it. Your doctor will decide whether you need the 2.5 mg/1000 mg or the 5 mg/1000 mg strength based on your current blood sugar control. Always take it at the same time each day for best results.

If you miss a dose, take it as soon as you remember with food. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.

• Stomach upset or diarrhea
• nausea or loss of appetite
• headache
• stuffy or runny nose
• mild joint pain

Alcohol — drinking alcohol while on this medicine can dangerously lower your blood sugar and increase the risk of lactic acidosis, so avoid or limit alcohol. Certain kidney scan dyes (contrast agents used for CT scans) can cause serious reactions — tell your doctor you are on this medicine before any scan. Other diabetes medicines like insulin or glimepiride may cause your blood sugar to drop too low when combined with this tablet.

Store below 30°C in a cool, dry place away from direct sunlight and humidity — avoid storing in bathrooms or near kitchen heat. Keep in the original pack and away from children.