Antidiabetic (combination of Biguanide and Sulfonylurea)
Brand of Metformin Hydrochloride; Glimepiride
Last reviewed June 2026
Who is this for?
This is a combination tablet containing two diabetes medicines — Metformin and Glimepiride — that work together to lower blood sugar. Metformin helps your body use insulin better and reduces the sugar your liver produces, while Glimepiride pushes your pancreas to release more insulin.
Inhibits hepatic glucose production by activating AMP-activated protein kinase (AMPK) and reducing mitochondrial glycerol-3-phosphate dehydrogenase activity, while glimepiride binds to ATP-sensitive potassium channels on pancreatic beta cells, stimulating insulin secretion to reduce blood glucose levels.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Take one tablet once or twice daily as your doctor prescribes, usually with your first main meal of the day (breakfast or lunch). Swallow the tablet whole with water — do not crush or chew it. Your doctor will start you on a low dose and increase it gradually based on your blood sugar readings.
If you miss a dose, take it as soon as you remember — but only if you are about to eat a meal. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Never take two doses at once as this can cause your blood sugar to drop dangerously low.
Always buy from a licensed pharmacy — brands like Co-Mepiryl, Diapride Plus, or Glepid Plus should come in proper sealed packaging; avoid buying diabetes medicines from roadside sellers or open markets. Always carry a small sugary snack or glucose sweet with you in case your blood sugar drops too low. Do not adjust your dose on your own — always follow your doctor's instructions and check your blood sugar regularly.
Alcohol can cause your blood sugar to drop dangerously low or increase the risk of lactic acidosis, so avoid or limit alcohol while on this medicine. NSAIDs like ibuprofen (commonly sold in Nigeria) can affect how well Glimepiride works and may increase the risk of low blood sugar. If you are taking blood pressure medicines, steroids, or other diabetes drugs, let your doctor know as they can affect your blood sugar control.
Check your specific combination
Is it safe to take Metformin with your other drugs?
This medicine is not safe during pregnancy or breastfeeding — if you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor immediately as you may need to switch to insulin.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tablets in their original pack and always store away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Co-Mepiryl Tablet 2 mg/500 mg
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NAFDAC Number
A4-2825
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