Antidiabetic (Biguanide + Sulfonylurea combination)
Last reviewed July 2026
Who is this for?
This is a combination medicine containing two diabetes drugs, Metformin and Gliclazide, that work together to lower blood sugar. Metformin helps your body use insulin better and reduces the sugar your liver makes, while Gliclazide pushes your pancreas to produce more insulin.
Inhibits hepatic gluconeogenesis and enhances insulin sensitivity through mitochondrial complex I suppression (metformin), while gliclazide stimulates pancreatic beta cells by blocking ATP-sensitive potassium channels, promoting insulin secretion to reduce postprandial and fasting hyperglycemia.
Type 2 diabetes (sugar disease), high blood sugar that diet and exercise alone cannot control
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it with your next meal. Do not take two tablets at once to make up for it, as this can cause your blood sugar to drop dangerously low.
Always buy from a registered pharmacy; brands like Diamin Plus, Glymed-M, or Melanov-M are available in Nigeria, so ask for them by name. Never adjust your dose on your own or share your diabetes medicine with someone else, even if they also have sugar disease. Keep glucose sweets or a sugary drink nearby in case your blood sugar drops too low, especially if you skip meals.
Alcohol can dangerously lower your blood sugar and increase the risk of lactic acidosis, so avoid or limit drinking. NSAIDs like ibuprofen (e.g. Ibrufen, Nurofen) can affect how these drugs work and may increase the risk of low blood sugar. If you are taking blood pressure medicines or steroids, tell your doctor as they can affect your sugar levels.
Check your specific combination
Is it safe to take Metformin with your other drugs?
This combination is not safe during pregnancy or breastfeeding. Consult your doctor immediately if you are pregnant, planning to become pregnant, or nursing a baby.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid storing near windows or in your car. Keep the tablets in their original pack and far from the reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.