Anti-diabetic (Biguanide + Sulfonylurea combination)
Brand of Metformin Hydrochloride; Glibenclamide
Last reviewed June 2026
Who is this for?
This is a combination diabetes tablet that contains two medicines — Metformin and Glibenclamide — that work together to lower blood sugar. Metformin helps your body use insulin better and reduces the sugar your liver releases, while Glibenclamide pushes your pancreas to produce more insulin.
Inhibits mitochondrial complex I, reducing hepatic glucose production and improving insulin sensitivity, while glibenclamide closes ATP-sensitive potassium channels in pancreatic beta cells, stimulating insulin secretion and enhancing glucose uptake by peripheral tissues.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Take the tablet with food, usually once or twice daily with your main meals like breakfast and dinner. Your doctor will start you on a low dose and gradually increase it. Swallow with a full glass of water. Do not skip meals after taking this drug, as it can cause your blood sugar to drop dangerously low (hypoglycaemia).
If you miss a dose, take it with your next meal. Do not take a double dose to make up for the one you missed — this can cause your blood sugar to drop too low, which is dangerous.
Always buy from a licensed pharmacy — brands like Glucovance, Breformide, or Clabetic — and avoid roadside sellers or unregistered drug shops, as fake diabetes drugs are common in Nigeria. Never share your diabetes medication with someone else, even if they also have sugar disease, because dosing must be personalised by a doctor. Always carry a small sugary snack like glucose sweet or juice in case your blood sugar drops too low.
Alcohol — drinking alcohol while on this drug can dangerously lower your blood sugar and increase the risk of lactic acidosis, so avoid or limit alcohol. NSAIDs like ibuprofen (e.g. Ibuprofen, Brufen) can increase the blood sugar-lowering effect and cause hypoglycaemia. If you are having a CT scan or X-ray with contrast dye, tell your doctor you are taking this medicine as it may need to be paused temporarily.
Check your specific combination
Is it safe to take Metformin with your other drugs?
This drug is not safe during pregnancy or breastfeeding — if you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor immediately as they will switch you to a safer option like insulin.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the container tightly closed to protect from humidity. Always keep out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Glucovance 500 mg/2.5 mg Tablet
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NAFDAC Number
04-7609
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