Lisinopril 20 mg + Hydrochlorothiazide 12.5 mg Tablet (Lisinopril; Hydrochlorothiazide) — Uses, Dosage & NAFDAC

Who is this for?

What is this drug?

This is a combination drug containing two blood pressure medicines — Lisinopril (which relaxes your blood vessels) and Hydrochlorothiazide (a 'water tablet' that helps your body get rid of extra salt and water through urine). Together, they lower high blood pressure more effectively than either one alone.

What is it used for?

High blood pressure (hypertension)

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High Blood Pressure

How it works

Inhibits angiotensin-converting enzyme (ACE), reducing angiotensin II formation and decreasing vasoconstriction and aldosterone secretion; simultaneously inhibits sodium reabsorption in the distal convoluted tubule through thiazide diuretic activity, promoting natriuresis and reducing circulating fluid volume to lower blood pressure.

Prescription Required

You need a doctor's prescription to buy this drug.

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Is Lisinopril; safe to take with another drug?

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How to take this drug

Take one tablet once daily, usually in the morning. You can take it with or without food, but try to take it at the same time every day. Drink enough water during the day. Your doctor may adjust your dose depending on how your blood pressure responds.

What if I Miss a Dose?

If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.

What to watch out for

Do not buy this medicine from roadside sellers or unregistered pharmacies — fake blood pressure drugs are dangerous and common. Do not stop taking it because you feel fine — high blood pressure often has no symptoms but still damages your heart, kidneys, and brain. Do not share this prescription with someone else who also has high blood pressure — their dose and drug choice may be different.

Common Side Effects

Dry cough (very common with this drug)
dizziness or feeling lightheaded especially when you stand up quickly
feeling tired or weak
passing urine more often than usual
headache

Serious Side Effects

Swelling of the face
lips
tongue or throat (this is an emergency — go to hospital immediately)
severe dizziness or fainting
signs of kidney problems like very little or no urine output or swelling in your legs

Drug Interactions

Potassium supplements or salt substitutes containing potassium — taking these with this drug can cause dangerously high potassium levels. Painkillers like ibuprofen and diclofenac (common in Nigeria) can reduce the blood pressure-lowering effect and harm your kidneys. Alcohol can make the dizziness and lightheadedness worse, so limit or avoid alcohol.

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Pregnancy & Breastfeeding Warning

This drug is NOT safe during pregnancy — it can cause serious harm or even death to your unborn baby, especially in the second and third trimesters. It is also not recommended while breastfeeding. Tell your doctor immediately if you become pregnant.

Who Should NOT Take This

People allergic to Lisinopril
Hydrochlorothiazide
or any sulfonamide drugs. People who have experienced swelling of the face or throat with previous blood pressure medicines. People with severe kidney failure or who cannot pass urine. People with diabetes who are taking Aliskiren. Pregnant women should not take this drug.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so do not leave it in your car or near a window. Keep the container tightly closed to protect from humidity. Always keep out of reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.

Lisinopril 20 mg + Hydrochlorothiazide 12.5 mg