Proton pump inhibitor + Prokinetic (stomach acid reducer and anti-nausea)
Last reviewed July 2026
Who is this for?
This is a combination drug containing esomeprazole (which reduces the amount of acid your stomach produces) and domperidone (which helps food move faster through your stomach and stops nausea and vomiting). Together, they tackle both excess stomach acid and the uncomfortable feeling of bloating or vomiting.
Inhibits gastric H+/K+-ATPase pump, suppressing acid secretion in parietal cells, while domperidone blocks dopamine receptors in the chemoreceptor trigger zone and enhances gastric motility, reducing nausea and accelerating gastric emptying.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, just skip the missed one and continue as normal. Do not take two doses at once to make up for the one you missed.
Only buy from licensed pharmacies and avoid roadside sellers or open market drugs, as fake versions are common in Nigeria. Do not use this drug for longer than your doctor or pharmacist recommended, as long-term use of acid-reducing drugs can cause other problems. Do not share your medication with others even if they have similar symptoms.
Avoid taking with ketoconazole or itraconazole (antifungal drugs commonly used in Nigeria) as they can interact badly with domperidone. Do not combine with alcohol as it can worsen stomach problems and increase drowsiness. Be careful if you are also taking blood thinners like warfarin, as esomeprazole can affect how they work.
Check your specific combination
Is it safe to take Esomeprazole; with your other drugs?
This drug is not recommended during pregnancy or breastfeeding unless your doctor says it is absolutely necessary. Consult your doctor before using it.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep it in its original pack and far away from children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.