Cough and Cold Combination (Expectorant, Antihistamine, Decongestant)
Last reviewed July 2026
Who is this for?
This is a combination cough medicine (known as Vadis Cough Expectorant in Nigeria) that contains three active ingredients: ephedrine which opens up your airways to help you breathe easier, diphenhydramine which is an antihistamine that reduces coughing and allergic symptoms, and ammonium chloride which helps loosen thick mucus (phlegm) so you can cough it out more easily.
Activates α-adrenergic receptors to cause vasoconstriction of nasal mucosa, while blocking H1 histamine receptors to reduce allergic symptoms; ammonium chloride acts as an expectorant by increasing respiratory tract secretions to facilitate mucus clearance.
Available Over The Counter
Get this from any pharmacy or chemist: no prescription needed.
Explore this drug
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, just skip the one you missed and continue as normal. Do not take a double dose to make up for it.
Buy only from reputable pharmacies; avoid roadside sellers or open market versions as they may be fake or expired. This medicine can make you very drowsy, so do not drive okada, keke, or any vehicle after taking it. Do not use for more than 7 days without seeing a doctor. If your cough is not improving, it could be something more serious that needs proper investigation.
Do not take with alcohol as it can make the drowsiness much worse and can be dangerous. Avoid taking with other cold or cough medicines as they may contain similar ingredients, leading to an overdose. If you are taking blood pressure medications, this drug (because of the ephedrine) can reduce their effectiveness, so talk to your pharmacist.
Check your specific combination
Is it safe to take Ephedrine with your other drugs?
This medicine is not recommended during pregnancy or breastfeeding. The ephedrine and diphenhydramine can affect your baby, so consult your doctor before using it.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the bottle tightly closed after use and always store out of reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.