Antiemetic (anti-nausea and vomiting medicine) / Prokinetic
Last reviewed July 2026
Who is this for?
Domperidone is a medicine that helps stop nausea and vomiting by blocking certain signals in your brain and speeding up the movement of food through your stomach so it doesn't sit there and make you feel sick.
Blocks dopamine receptors in the chemoreceptor trigger zone and gastric smooth muscle, thereby suppressing nausea and vomiting while enhancing gastric motility and accelerating gastric emptying. Acts peripherally without crossing the blood-brain barrier significantly, making it suitable for prolonged use with minimal central nervous system effects.
Available Over The Counter
Get this from any pharmacy or chemist: no prescription needed.
Explore this drug
If you miss a dose, just skip it and take the next one at the usual time before your next meal. Do not take two doses at once to make up for it.
Do not use domperidone for more than one week without a doctor's advice, as long-term use can affect your heart. Buy only from a registered pharmacy, not roadside sellers, to make sure you are getting genuine Motilium or a quality generic. If your vomiting does not improve after a few days, see a doctor, as it could be a sign of something more serious.
Avoid taking domperidone with ketoconazole (antifungal) or erythromycin (antibiotic) as the combination can cause dangerous heart rhythm problems. Avoid alcohol as it can worsen nausea and increase drowsiness. Also be careful if you are taking heart medications, and inform your doctor or pharmacist.
Check your specific combination
Is it safe to take Domperidone with your other drugs?
Domperidone is not recommended during pregnancy or breastfeeding unless your doctor specifically prescribes it, as it can pass into breast milk and may affect milk production.
Store in a cool, dry place away from direct sunlight and heat, as Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the pack tightly closed to protect from humidity and always keep it out of reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.