Combination topical steroid, antifungal, and antibiotic
Last reviewed July 2026
Who is this for?
This is a combination cream containing three active ingredients: clobetasol (a very strong steroid that reduces swelling, redness, and itching), ketoconazole (an antifungal that kills fungal infections), and neomycin (an antibiotic that kills bacteria). Together, they treat skin conditions where infection, fungus, and inflammation are all present at the same time.
Binds to glucocorticoid receptors to suppress inflammatory cytokines and immune response, inhibits fungal ergosterol synthesis via lanosterol 14α-demethylase blockade, and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, providing combined anti-inflammatory, antifungal, and antibacterial activity.
Stubborn skin rashes with infection, ringworm with inflammation, eczema with fungal or bacterial infection, itching skin conditions complicated by infection, dermatitis with secondary infection
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you forget to apply the cream, apply it as soon as you remember. But if it is almost time for your next application, just skip the missed one and continue your normal routine. Do not apply double the amount to make up for it.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Do not use this cream longer than 2 weeks without a doctor's supervision, as long-term use of strong steroids can permanently damage your skin. Buy only from reputable pharmacies and look for known brands like 3-Xon Cream, Baseheal Cream, Fotax Cream, or Greenzoral Plus Cream. Do not share your cream with others even if they seem to have the same skin problem, as their condition may need a different treatment.
Avoid using other steroid creams or medicated skin products on the same area at the same time, as this can increase side effects. If you are using any other antibiotic cream, let your doctor know to avoid antibiotic overload. Do not cover the area with tight bandages or nylon after applying unless your doctor says so, as this increases absorption of the steroid.
Check your specific combination
Is it safe to take Clobetasol; with your other drugs?
This cream is not considered safe during pregnancy or breastfeeding, so do not use it without consulting your doctor first, especially on large skin areas or for a long time.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the tube tightly closed after use. Always keep it out of the reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.