How do you take Clindamycin (Clindamycin Phosphate); Clotrimazole?

For adults, insert one vaginal suppository, tablet, or capsule deep into the vagina at bedtime, usually once daily for 3 to 7 days depending on your doctor's instruction. Wash your hands before and after insertion. Lie down after inserting so the medicine stays in place. Complete the full course even if you feel better after a few days.

What are the side effects of Clindamycin (Clindamycin Phosphate); Clotrimazole?

Mild vaginal itching or burning after insertion, slight vaginal discharge, mild stomach cramps or bloating, skin irritation around the vaginal area

Who should not take Clindamycin (Clindamycin Phosphate); Clotrimazole?

Women who are allergic to clindamycin, lincomycin, clotrimazole, or any ingredient in the product. Women with a history of antibiotic-associated colitis (serious bowel inflammation from antibiotics). Do not use in children or before puberty. Men should not use this product.

Prescription

Antibiotic and Antifungal combination

Clindamycin; Clotrimazole

Q: What is Clindamycin (Clindamycin Phosphate); Clotrimazole used for?

Vaginal infections (discharge, itching, odour), bacterial vaginosis, vaginal yeast infections (candidiasis), mixed vaginal infections

Last reviewed July 2026

Who is this for?

For adults (18+). Standard adult dosing applies: see the How to Take tab for full instructions.

What is this drug?

This is a combination medicine containing clindamycin (an antibiotic that kills harmful bacteria) and clotrimazole (an antifungal that fights yeast/fungal infections). Together, they treat mixed vaginal infections caused by both bacteria and fungi at the same time.

How it works

Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, while clotrimazole disrupts fungal cell membrane integrity by inhibiting lanosterol 14α-demethylase, collectively eliminating polymicrobial vaginal infections.

What is it used for?

Vaginal infections (dischargeitchingodour)bacterial vaginosisvaginal yeast infections (candidiasis)mixed vaginal infections

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Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Always complete the full course of treatment even if symptoms disappear, as stopping early can cause the infection to return stronger. Buy only from reputable pharmacies, not roadside vendors, to ensure proper storage and authenticity. Do not share this medication with anyone else, even if they have similar symptoms, as they need to see a doctor for their own diagnosis.

Common Side Effects

Mild vaginal itching or burning after insertion
slight vaginal discharge
mild stomach cramps or bloating
skin irritation around the vaginal area

Serious Side Effects

Severe allergic reaction such as swelling of the face
tongue or throat and difficulty breathing: go to the hospital immediately. Severe or worsening vaginal irritation
rash
or blistering: stop using and see a doctor right away. Persistent watery or bloody diarrhoea: this could signal a serious gut problem and needs urgent medical attention.

Drug Interactions

Avoid using other vaginal creams, suppositories, or douches at the same time unless your doctor says so, as they can reduce the effectiveness. Clindamycin may reduce the strength of latex condoms and diaphragms, so use alternative protection during treatment. If you are taking erythromycin (another antibiotic), tell your doctor because it can interfere with clindamycin.

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Pregnancy & Breastfeeding Warning

Do not use this medicine during pregnancy or while breastfeeding unless your doctor specifically prescribes it, so always consult your doctor first.

Who Should NOT Take This

Women who are allergic to clindamycin
lincomycin
clotrimazole
or any ingredient in the product. Women with a history of antibiotic-associated colitis (serious bowel inflammation from antibiotics). Do not use in children or before puberty. Men should not use this product.

How to Store

Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can melt suppositories, so keep them in a cupboard or even the refrigerator if needed. Keep out of reach of children. Do not use after the expiry date on the pack.

For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.