Sulfonylurea (Antidiabetic)
Last reviewed July 2026
Who is this for?
Chlorpropamide is a diabetes medicine that works by pushing your pancreas to produce more insulin, which helps lower the sugar level in your blood.
Binds to ATP-sensitive potassium channels on pancreatic beta cells, closing them and depolarizing the cell membrane to trigger insulin secretion. This increases circulating insulin levels, enhancing glucose uptake by peripheral tissues and reducing blood glucose concentration.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember, but only if it is still the same morning. If it is already late in the day or close to your next dose, skip the missed one and continue as normal. Never take two doses at once to make up for it.
Always buy from a reputable pharmacy and avoid roadside sellers or unregistered shops, especially for diabetes medicines like Decnese Tablets. Learn to recognize the signs of low blood sugar (shakiness, sweating, confusion) and always carry a sugary snack or drink with you. Do not adjust your dose on your own: always consult your doctor before changing how much you take.
Alcohol can cause a very bad reaction with chlorpropamide, so you may experience severe flushing, headache, nausea, and dangerously low blood sugar. Avoid drinking alcohol while on this drug. NSAIDs like ibuprofen (e.g. Brufen) can increase its effect and cause your sugar to drop too low. Blood pressure medicines called beta-blockers can hide the warning signs of low blood sugar.
Check your specific combination
Is it safe to take Chlorpropamide with your other drugs?
Chlorpropamide is not safe during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or nursing, talk to your doctor immediately about switching to a safer option like insulin.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it near windows or in your car. Keep it in its original container and far from children's reach.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.