How do you take Chlorhexidine Gluconate?

This medicine is for external use only; never swallow it. For skin cleaning, apply the solution or scrub to the affected area and rub gently, then rinse with water if directed. For mouthwash, rinse your mouth with about 10ml (two teaspoons) for 30 seconds to 1 minute, then spit it out; do not swallow. For umbilical cord gel, apply a small amount to the baby's cord stump as directed by your nurse or doctor.

What are the side effects of Chlorhexidine Gluconate?

Mild skin irritation or dryness at the area where it is applied, temporary change in taste if using the mouthwash, slight staining of teeth with prolonged mouthwash use, mild burning or tingling sensation on the skin

Who should not take Chlorhexidine Gluconate?

People who have ever had an allergic reaction to chlorhexidine should not use it. Do not use it inside the ears, eyes, or on the brain or spinal cord area. Avoid using it on large open wounds or deep cuts without a doctor's guidance.

OTC

Antiseptic

Chlorhexidine Gluconate

Last reviewed July 2026

Who is this for?

For adults (18+). Standard adult dosing applies: see the How to Take tab for full instructions.

What is this drug?

Chlorhexidine gluconate is an antiseptic (germ-killing) medicine that works by destroying bacteria and other germs on the skin and surfaces, preventing infections from spreading.

How it works

Binds to and disrupts bacterial cell membranes and denatures proteins, causing loss of cellular integrity and microbial death; also inhibits bacterial metabolism by interfering with enzyme function. Effective against a broad spectrum of gram-positive and gram-negative bacteria, fungi, and some viruses through these mechanisms of membrane destabilization.

What is it used for?

Wound cleaning, surgical hand scrub, skin disinfection before surgery or injections, umbilical cord care for newborns, mouth wash for gum infections and mouth sores, general skin antisepsis

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Toothache & Dental Sepsis & Severe Infections Topical Antibiotics & Antiseptics Wound Care & Antiseptics

Available Over The Counter

Get this from any pharmacy or chemist: no prescription needed.

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What to watch out for

Make sure you buy from a reputable pharmacy and avoid buying antiseptics from roadside sellers or open markets where storage conditions may be poor. This medicine is for external use only; if anyone accidentally swallows it, take them to the hospital immediately. For newborn cord care, use only products specifically made for that purpose like Umblicare Gel or Umbygene Gel, and follow your midwife's instructions carefully.

Common Side Effects

Mild skin irritation or dryness at the area where it is applied
temporary change in taste if using the mouthwash
slight staining of teeth with prolonged mouthwash use
mild burning or tingling sensation on the skin

Serious Side Effects

Severe allergic reaction such as swelling of the face
lips
or throat and difficulty breathing: go to the hospital immediately. Serious skin reaction like blistering
peeling
or deep rash: stop using it and see a doctor right away.

Drug Interactions

Do not use chlorhexidine together with soap or other detergents at the same time, as soap can cancel out its germ-killing power; rinse off soap first before applying. Avoid using it with iodine-based antiseptics (like Betadine) on the same area, as they can interfere with each other. There are no major food or alcohol interactions since it is not swallowed.

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Pregnancy & Breastfeeding Warning

Chlorhexidine is generally considered safe for use on the skin during pregnancy and breastfeeding, but always inform your doctor or midwife before using it.

Who Should NOT Take This

People who have ever had an allergic reaction to chlorhexidine should not use it. Do not use it inside the ears
eyes
or on the brain or spinal cord area. Avoid using it on large open wounds or deep cuts without a doctor's guidance.

How to Store

Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it on window sills or inside cars. Keep the container tightly closed and store out of reach of children. Do not freeze the product.

For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.