Combination anti-infective and anti-inflammatory (steroid, antifungal, antibiotic)
Last reviewed July 2026
Who is this for?
This is a combination cream or lotion containing four active ingredients: betamethasone (a steroid that reduces swelling, redness, and itching), tolnaftate (an antifungal that kills fungus), gentamicin (an antibiotic that fights bacteria), and clioquinol (which fights both fungus and bacteria). Together, they treat skin infections caused by a mix of germs.
Inhibits fungal ergosterol synthesis (tolnaftate and clioquinol), suppresses bacterial protein synthesis via 30S ribosomal subunit inhibition (gentamicin), and activates glucocorticoid receptors to reduce inflammatory mediators and immune cell proliferation (betamethasone), providing combined antimicrobial and anti-inflammatory action against mixed cutaneous infections.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you forget to apply it, use it as soon as you remember. If it is almost time for your next application, just skip the missed one and continue as normal. Do not apply double the amount to make up for it.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Do not use this cream to bleach or lighten your skin, as many Nigerians misuse steroid creams for toning, which causes serious long-term skin damage. Complete the full course of treatment even if the rash looks better, to prevent the infection from coming back. Buy only from registered pharmacies and look for known brands like Dermacol Cream, Epiderm Cream, Fungiban Cream, Fexotop Cream, or Visiderm Cream, and avoid unregistered products from roadside sellers.
Avoid using other steroid creams or medicated skin products on the same area at the same time, as this can increase side effects. If you are taking blood-thinning medications like warfarin, let your doctor know. Do not mix with other antibiotic creams unless a doctor advises you to.
Check your specific combination
Is it safe to take Betamethasone; with your other drugs?
Do not use during pregnancy or breastfeeding unless a doctor specifically prescribes it, as the steroid and other ingredients may affect the baby.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in a car or near a window. Keep the cap tightly closed and store out of reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.