Question 1

What is Alpelisib used for?

Accepted Answer

Advanced breast cancer (specifically hormone receptor-positive, HER2-negative breast cancer that has a PIK3CA gene change), used together with another cancer drug called fulvestrant

Question 2

How do you take Alpelisib?

Accepted Answer

The usual adult dose is 300 mg taken once daily by mouth. Take it immediately after eating food — this is very important to reduce side effects like nausea and high blood sugar. Swallow the tablets whole, do not crush or chew them. Your oncologist (cancer doctor) will tell you exactly how to combine it with fulvestrant injections.

Question 3

What are the side effects of Alpelisib?

Accepted Answer

High blood sugar (you may feel very thirsty, urinate often, or feel tired), diarrhoea, skin rash or dry skin, nausea or loss of appetite, feeling very tired or weak

Question 4

Who should not take Alpelisib?

Accepted Answer

People allergic to alpelisib or any ingredient in Pivikto tablets, people with a history of severe allergic skin reactions like Stevens-Johnson syndrome, people with poorly controlled diabetes or very high blood sugar, and anyone whose cancer does not have the specific PIK3CA gene change (your doctor must confirm this with a test before starting treatment).

Question 5

Is Alpelisib safe during pregnancy?

Accepted Answer

Alpelisib is NOT safe during pregnancy or breastfeeding — it can seriously harm an unborn baby, so women must use effective contraception during treatment and for at least one week after the last dose.

Alpelisib

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