Anti-inflammatory enzyme (Proteolytic enzyme)
Last reviewed June 2026
Who is this for?
Trypsin and Bromelain is a combination of natural enzymes (proteins that speed up body processes) that help reduce swelling, inflammation, and pain by breaking down damaged tissue and improving blood flow to injured areas.
Cleaves fibrin, fibrinogen, and extracellular matrix proteins through serine protease activity, reducing inflammatory exudate accumulation and promoting tissue remodeling. Activates complement cascade degradation and enhances phagocytic clearance of damaged tissue and inflammatory mediators, facilitating resolution of edema and inflammation.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
Take 1 to 2 tablets two to three times daily, preferably 30 minutes before meals or as directed by your doctor. Swallow whole with water — do not crush or chew the tablet. The common Nigerian brand is Kotase Tablet.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for it.
Buy only from reputable pharmacies — avoid roadside sellers or open market drugs as enzyme tablets are sensitive to heat and may lose their potency. Do not crush or chew the tablets as the coating protects them from stomach acid. If swelling or pain does not improve after a few days, see your doctor rather than increasing the dose on your own.
Blood-thinning medications like warfarin or aspirin — taking them together can increase the risk of bleeding. Certain antibiotics like tetracycline and amoxicillin may interact with these enzymes. Avoid taking with alcohol as it may worsen stomach irritation.
Check your specific combination
Is it safe to take Trypsin; with your other drugs?
Pregnant and breastfeeding women should consult their doctor before taking this medication, as safety has not been fully established.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tablets in their original pack and out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.