Retinoid (Vitamin A derivative for skin)
Brand of Tretinoin
Last reviewed June 2026
Who is this for?
Tretinoin is a vitamin A-based cream that works by speeding up the way your skin renews itself — it helps old, damaged skin cells shed faster and encourages fresh, healthy skin to grow underneath.
Binds to retinoic acid receptors (RAR) in skin cells, promoting cell turnover, reducing sebum production, and increasing collagen synthesis to improve acne lesions, skin texture, and photoaging. Normalizes keratinocyte differentiation and inhibits comedone formation while enhancing epidermal renewal.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Apply a thin layer to clean, dry skin once a day at night before bed. Wash your face first and wait about 20-30 minutes for your skin to fully dry before applying. Use only a pea-sized amount for the whole face. Start with the lower strength (0.025%) to let your skin adjust. Avoid getting it near your eyes, nostrils, mouth corners, or broken skin.
If you forget to apply it at night, just skip that night and apply it the next evening as usual. Do not apply extra cream to make up for a missed application.
Always use sunscreen (at least SPF 30) during the day when using tretinoin because it makes your skin burn much faster in the sun — this is very important in Nigeria's strong sunlight. Buy only from reputable pharmacies — products like Acretin, Ratin-A, Leetina-A, and Alisar are known brands in Nigeria, so avoid unbranded or roadside versions as they may contain harmful ingredients. Be patient — tretinoin takes 6 to 12 weeks to show real results, and your skin may look worse before it gets better, so do not give up too early.
Avoid using other strong skin products like benzoyl peroxide, salicylic acid, or harsh scrubs at the same time as tretinoin — they can cause severe irritation. Do not use skin-lightening products containing hydroquinone or mercury-based creams alongside tretinoin without a doctor's guidance. Avoid products with alcohol or astringents as they will dry out your skin further.
Check your specific combination
Is it safe to take Tretinoin with your other drugs?
Tretinoin is NOT safe during pregnancy or if you are planning to become pregnant, as it can harm the unborn baby — also consult your doctor before using it while breastfeeding.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so keep it in a cupboard or drawer, not on a window sill or in your car. Keep the tube tightly closed and away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Leetina-A Cream 30 g
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NAFDAC Number
A4-100710
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