Rifalab Forte Caplets

Who is this for?

Rifampicin is a strong antibiotic that works by killing bacteria and stopping them from multiplying — it does this by blocking the bacteria's ability to make the proteins they need to survive.

Binds to bacterial RNA polymerase, inhibiting transcription and RNA synthesis, leading to disruption of bacterial protein production and cell death.

Is Rifampicin safe to take with another drug?

For TB, the usual adult dose is 450mg to 600mg once daily (typically 600mg if you weigh 50kg or more). Take it on an empty stomach — at least 30 minutes before food or 2 hours after eating — with a full glass of water. Your doctor will tell you the exact dose and how long to take it, which is usually several months.

If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one and continue your normal schedule. Never take two doses at once to make up for it.

• Orange-red discolouration of urine
• tears
• sweat and saliva (this is normal and harmless)
• stomach upset or nausea
• loss of appetite
• mild headache
• itching or skin rash

Rifampicin reduces the effectiveness of birth control pills — use an additional method like condoms while on treatment. It also reduces the effect of HIV drugs (antiretrovirals), so your doctor must adjust doses. Avoid alcohol completely, as combining it with rifampicin greatly increases the risk of liver damage.

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it on windowsills or in cars. Keep the container tightly closed to protect from humidity, and always keep it out of children's reach.