Enzymatic wound debriding agent
Brand of Papain; Urea
Last reviewed June 2026
Who is this for?
Papain and Urea is a topical ointment that works by breaking down and removing dead or damaged skin tissue from wounds, burns, and ulcers so that healthy new skin can grow underneath. Papain is an enzyme from papaya that digests dead tissue, while urea helps soften and activate it.
Catalyzes proteolytic digestion of necrotic tissue and fibrin through enzymatic degradation of denatured proteins, while urea enhances tissue penetration and promotes autolytic debridement of sloughy wounds and eschar.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
This is not a tablet — it is an ointment applied directly to the wound. Clean the wound gently first, then apply a thin layer of the ointment (like Debridace Ointment) to the affected area once or twice daily as directed by your doctor. Cover with a clean bandage after applying.
If you forget to apply it, apply it as soon as you remember. If it is almost time for the next application, skip the missed one and continue your regular schedule. Do not apply double the amount to make up for a missed dose.
Only buy from reputable pharmacies — products like Debridace Ointment should be properly sealed and not expired, especially in hot Nigerian conditions. Do not use local or herbal wound powders together with this ointment without asking your doctor. If you are diabetic and have a foot ulcer, always let your doctor supervise wound care rather than managing it alone at home.
Do not use with silver-containing wound products (like silver sulfadiazine cream) as silver can reduce the effectiveness of papain. Avoid using hydrogen peroxide on the wound at the same time as this ointment, as it may interfere with the enzyme action. Heavy metals in some traditional wound remedies may also reduce how well it works.
Check your specific combination
Is it safe to take Papain; with your other drugs?
Consult your doctor before using this ointment during pregnancy or while breastfeeding, as there is limited safety data — but since it is applied on the skin and not taken by mouth, your doctor may still recommend it if needed.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in cars or near windows. Keep the tube tightly closed after use and store away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Debridace Ointment
Packaging image coming soon
We're building our packaging database — check back soon
NAFDAC Number
B4-8268
Verify Your Pack