Proton Pump Inhibitor + Antibiotics (Triple Therapy for Ulcer)
Last reviewed June 2026
Who is this for?
This is a combination of three medicines — Omeprazole (which reduces stomach acid), Tinidazole (an antibiotic that kills certain bacteria), and Clarithromycin (another antibiotic) — all working together to clear a stomach infection caused by a germ called H. pylori that causes ulcer.
Omeprazole inhibits the H+/K+-ATPase pump in gastric parietal cells, suppressing gastric acid secretion and creating an optimal environment for bacterial eradication. Tinidazole and clarithromycin exert bactericidal activity against H. pylori by disrupting bacterial DNA synthesis and inhibiting protein translation, respectively, thereby eliminating the pathogenic organism and allowing ulcer healing.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
The usual adult dose is to take all three medicines together twice a day — typically Omeprazole 20mg, Tinidazole 500mg, and Clarithromycin 250mg or 500mg — morning and evening for 7 to 14 days. Take them with food or just before eating. Swallow the capsules and tablets whole with water, do not crush or chew. In Nigeria, you may find this combination already packed together as Ulsakit Softgels.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take double doses to make up for the one you missed.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Complete the full course of treatment even if you feel better after a few days — stopping early can make the bacteria resistant and your ulcer can come back worse. Do not buy antibiotics from roadside sellers or open market vendors as they may be fake or expired. Do not share this prescription medicine with anyone else, even if they have similar symptoms.
Do not drink alcohol while taking this medicine — Tinidazole reacts badly with alcohol and can cause severe nausea, vomiting, and cramps. Avoid taking this with blood-thinning medicines like Warfarin without your doctor's knowledge, as it may increase the risk of bleeding. If you are taking medications like Diazepam, Carbamazepine, or any HIV drugs, tell your doctor or pharmacist before starting this combination.
Check your specific combination
Is it safe to take Omeprazole; with your other drugs?
This combination is not safe during pregnancy or breastfeeding — do not take it without consulting your doctor first.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep the medicines in their original pack and far away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.