Cholinesterase inhibitor (muscle function enhancer)
Last reviewed July 2026
Who is this for?
Neostigmine is an injection that works by increasing the activity of a natural chemical called acetylcholine in your body, which helps muscles contract and work properly.
Inhibits acetylcholinesterase enzyme, preventing breakdown of acetylcholine at the neuromuscular junction and increasing available acetylcholine to bind muscarinic and nicotinic receptors, thereby enhancing muscle contraction and function.
Myasthenia gravis (a condition that causes severe muscle weakness), reversal of muscle relaxation after surgery, post-operative bloating and inability to urinate
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Since neostigmine is given by a doctor or nurse in a hospital, missed doses are unlikely. If you are on a scheduled dosing plan, contact your doctor as soon as you remember so they can advise you.
This is a hospital-only drug, so never attempt to buy or inject it yourself from a chemist or roadside seller. Always make sure it is administered by a qualified healthcare professional. If you have myasthenia gravis, carry a medical ID card so emergency responders know your condition.
Atropine is sometimes given alongside neostigmine to reduce its side effects like excess saliva and slow heartbeat. Certain antibiotics like gentamicin and other aminoglycosides can reduce how well neostigmine works. Drugs used for muscle relaxation during surgery (like suxamethonium) can interact dangerously with neostigmine.
Check your specific combination
Is it safe to take Neostigmine with your other drugs?
Neostigmine should only be used during pregnancy or breastfeeding if your doctor decides the benefit outweighs the risk, so always consult your doctor.
Store below 25°C in a cool, dry place away from direct sunlight and heat, which is important in Nigeria's hot climate. Keep out of reach of children. Do not use if the solution looks cloudy or discoloured.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.