Klovinal Pessaries Pessary (Metronidazole; Clotrimazole; Lactobacillus) — Uses, Dosage & NAFDAC

Who is this for?

What is this drug?

This is a vaginal pessary (insert) that combines three active ingredients: metronidazole (an antibiotic that kills harmful bacteria), clotrimazole (an antifungal that kills yeast/fungus), and lactobacillus (a friendly bacteria that helps restore the natural balance in your vagina).

What is it used for?

Vaginal infectionsvaginal dischargevaginal itchingbacterial vaginosis (BV)vaginal yeast infection (candidiasis)mixed vaginal infections

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Fungal Infections

How it works

Metronidazole inhibits bacterial nucleic acid synthesis by forming cytotoxic intermediates that damage DNA in anaerobic organisms; Clotrimazole inhibits fungal ergosterol synthesis by blocking lanosterol 14α-demethylase (CYP51), disrupting fungal cell membrane integrity; Lactobacillus restores normal vaginal microbiota by producing lactic acid and bacteriocins, thereby suppressing pathogenic organisms and re-establishing vaginal pH homeostasis.

Prescription Required

You need a doctor's prescription to buy this drug.

Quick Interaction Check

Is Metronidazole; safe to take with another drug?

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How to take this drug

Insert one pessary deep into the vagina at bedtime for 7 nights or as your doctor prescribes. Wash your hands before and after insertion. Lie down after inserting so it stays in place. It is best used at night so the medicine works while you sleep. Klovinal is the popular Nigerian brand.

What if I Miss a Dose?

If you miss a dose at bedtime, insert it as soon as you remember. If it is already morning, skip that dose and insert the next one at bedtime as usual. Do not use two pessaries at once to make up for the missed dose.

Important for antibiotics

Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.

What to watch out for

Complete the full course even if you start feeling better after a few days — stopping early can make the infection come back stronger. Buy only from a reputable pharmacy and check the expiry date, especially for Klovinal pessaries. Do not share this medicine with another person — her infection may be different from yours and needs proper diagnosis.

Common Side Effects

Mild vaginal burning or irritation after insertion
slight increase in discharge as the medicine works
mild stomach discomfort or cramps
itching around the vaginal area

Serious Side Effects

Severe allergic reaction such as swelling
rash all over the body
or difficulty breathing — go to the hospital immediately. Intense burning
blistering
or heavy unusual discharge that gets worse instead of better — stop using and see a doctor.

Drug Interactions

Avoid drinking alcohol while using this medicine — metronidazole and alcohol together can cause serious nausea, vomiting, and stomach cramps. If you are using blood thinners like warfarin, tell your doctor as metronidazole can increase their effect. Avoid using other vaginal creams or inserts at the same time unless your doctor says so.

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Is it safe to take Metronidazole; with your other drugs?

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Pregnancy & Breastfeeding Warning

Do not use during the first three months of pregnancy; if you are pregnant or breastfeeding, consult your doctor before using this medicine.

Who Should NOT Take This

Women who are allergic to metronidazole
clotrimazole
or any of the ingredients should not use it. Women in their first trimester of pregnancy should avoid it. Do not use if you have a history of blood disorders or serious liver problems.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can melt pessaries, so keep them in a cool part of your room or even a refrigerator if the weather is very hot. Keep out of reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.

Klovinal Pessaries