Isoniazid Tablets Bp 300 mg (check product description)

Who is this for?

Isoniazid is an antibiotic specifically designed to fight tuberculosis (TB) bacteria. It works by stopping the TB germs from building their protective walls, which kills them off over time.

Inhibits mycobacterial cell wall synthesis by blocking mycolic acid production through inhibition of InhA (enoyl-ACP reductase) after hepatic activation to its active metabolite. This disrupts the integrity of the mycobacterial cell envelope, leading to bacterial cell death.

Is Isoniazid safe to take with another drug?

For active TB treatment, the usual adult dose is 300 mg (one 300 mg tablet) taken once daily on an empty stomach — ideally 1 hour before food or 2 hours after eating. Your doctor will combine it with other TB drugs. For TB prevention, the dose is also 300 mg once daily, usually for 6 to 9 months. Always follow your doctor's exact instructions and never stop early even if you feel better.

If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two doses at once to make up for it.

• Tingling or numbness in the hands and feet
• mild nausea or stomach upset
• feeling tired or weak
• loss of appetite
• mild skin rash

Alcohol — drinking alcohol while on isoniazid greatly increases your risk of liver damage, so avoid alcohol completely during treatment. Paracetamol — using paracetamol regularly alongside isoniazid can also stress your liver, so use it sparingly and only when necessary. Antacids like aluminium hydroxide (commonly sold in Nigerian pharmacies) can reduce how well isoniazid works — take them at least 1 hour apart.

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid storing it near windows or in your car. Keep the container tightly closed to protect from moisture, and always keep it out of the reach of children.